Pulse doppler and M-mode to assess viability of cardiac allografts using heterotopic femoral heart transplantation in rats

Chad R. Gordon, Daniel R. Lefebvre, Martha S. Matthews, Louise F. Strande, Steven W. Marra, Massimiliano Guglielmi, Jad Skaf, Steven M. Hollenberg, Charles W. Hewitt

Research output: Contribution to journalArticlepeer-review

Abstract

Noninvasive assessment of heterotopic heart transplants using Doppler echocardiography was first described in two patients by Allen at Stanford in 1981. Since then, numerous experiments studying heterotopic heart transplantation in humans and large animals have confirmed its utility by employing either an intra-abdominal or cervical model. In rats, however, prior research investigating intra-abdominal heterotopic hearts has showed echocardiography to be ineffective. We have recently developed a new technique for heterotopic femoral heart transplantation in rats, which employs the novel use of trans-femoral echocardiography. Therefore, our goal was to re-examine the efficacy of echocardiography for detection of graft rejection.

Original languageEnglish (US)
Pages (from-to)240-244
Number of pages5
JournalMicrosurgery
Volume27
Issue number4
DOIs
StatePublished - Jun 15 2007
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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