Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1

Gregg L. Semenza

doi:10.1513/pats.200404-029MS

Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1

Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed.

Original language	English (US)
Pages (from-to)	68-70
Number of pages	3
Journal	Proceedings of the American Thoracic Society
Volume	2
Issue number	1
DOIs	https://doi.org/10.1513/pats.200404-029MS
State	Published - 2005

Keywords

Gene expression
Oxygen sensing
Pulmonary hypertension

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1513/pats.200404-029MS

Cite this

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abstract = "Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed.",

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AB - Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed.

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Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1

Abstract

Keywords

ASJC Scopus subject areas

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