TY - JOUR
T1 - Pulmonary toxicity syndrome following CDEP (cyclophosphamide, dexamethasone, etoposide, cisplatin) chemotherapy
AU - Fassas, A.
AU - Gojo, I.
AU - Rapoport, A.
AU - Cottler-Fox, M.
AU - Meisenberg, B.
AU - Papadimitriou, J. C.
AU - Tricot, G.
PY - 2001
Y1 - 2001
N2 - We report on three patients with multiple myeloma who developed drug-induced pneumonitis 1-2 1/2 months following maintenance (post autologous transplantation) chemotherapy with CDEP (cyclophosphamide, dexamethasone, etoposide, cisplatin) and 6-20 months after exposure to carmustine (BCNU) 300 mg/m2, used in combination with melphalan 140 mg/m2, as pre-transplant conditioning regimen. All patients had either a proven (two) or suspected (one) fungal pneumonia and were treated with liposomal amphotericin B. Dyspnea, fever and cough were the prominent clinical symptoms, while air-space disease with ground glass appearance was seen radiographically. Histologic features typical for drug-induced lung injury were detected. All patients had a dramatic, clinical and radiographic response to a brief course of corticosteroids. Although CDEP-induced pneumonitis appears to be a rare complication, its early recognition and prompt treatment, as well as its possible association with preceding fungal infection may have important clinical implications.
AB - We report on three patients with multiple myeloma who developed drug-induced pneumonitis 1-2 1/2 months following maintenance (post autologous transplantation) chemotherapy with CDEP (cyclophosphamide, dexamethasone, etoposide, cisplatin) and 6-20 months after exposure to carmustine (BCNU) 300 mg/m2, used in combination with melphalan 140 mg/m2, as pre-transplant conditioning regimen. All patients had either a proven (two) or suspected (one) fungal pneumonia and were treated with liposomal amphotericin B. Dyspnea, fever and cough were the prominent clinical symptoms, while air-space disease with ground glass appearance was seen radiographically. Histologic features typical for drug-induced lung injury were detected. All patients had a dramatic, clinical and radiographic response to a brief course of corticosteroids. Although CDEP-induced pneumonitis appears to be a rare complication, its early recognition and prompt treatment, as well as its possible association with preceding fungal infection may have important clinical implications.
KW - CDEP chemotherapy
KW - Fungal infection
KW - Non-infective pulmonary toxicity
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U2 - 10.1038/sj.bmt.1703147
DO - 10.1038/sj.bmt.1703147
M3 - Article
C2 - 11571514
AN - SCOPUS:0034823765
SN - 0268-3369
VL - 28
SP - 399
EP - 403
JO - Bone marrow transplantation
JF - Bone marrow transplantation
IS - 4
ER -