Pulmonary toxicity of the insecticide fenitrothion in the rat following a single field exposure

P. A. Coulombe, S. Lortie, M. G. Cote, G. Chevalier

Research output: Contribution to journalArticle

Abstract

The pulmonary toxicity of the organophosphorus insecticide fenitrothion was evaluated following a single exposure of rats to the field formulation, at the site of an aerial spraying. Four groups of 40 Sprague-Dawley rats (including a control), set in wood enclosures, were placed under aerial lines of the spraying aircraft. The degree of exposure was monitored at the ground level by air sampling and visual evidence of droplet activity deposition. Plasma pseudocholinesterase activity and pulmonary alveoli ultrastructure were used as indices to the fenitrothion exposure. Rat lungs were examined under light and electron microscopy at days 3, 7, 21, 60 and 180 after the exposure. Although a few signs of toxic lung injury were observed at days 3 and 7 there was no cholinergic crisis nor an effect on the pseudocholinesterase activity within 12 h in the exposed animals, when compared with controls. The alveolar toxic reaction was limited to small and discrete foci, and was entirely reversible within a period of 2 months. On a morphological basis it is thus concluded that a single field exposure to fenitrothion did not induce any permanent change in the alveolar area of the rat lung.

Original languageEnglish (US)
Pages (from-to)317-323
Number of pages7
JournalJournal of Applied Toxicology
Volume6
Issue number5
StatePublished - 1986
Externally publishedYes

Fingerprint

Fenitrothion
Insecticides
Pseudocholinesterase
Toxicity
Rats
Poisons
Lung
Spraying
Pulmonary Alveoli
Aircraft
Lung Injury
Antennas
Cholinergic Agents
Sprague Dawley Rats
Electron Microscopy
Enclosures
Air
Electron microscopy
Optical microscopy
Light

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Coulombe, P. A., Lortie, S., Cote, M. G., & Chevalier, G. (1986). Pulmonary toxicity of the insecticide fenitrothion in the rat following a single field exposure. Journal of Applied Toxicology, 6(5), 317-323.

Pulmonary toxicity of the insecticide fenitrothion in the rat following a single field exposure. / Coulombe, P. A.; Lortie, S.; Cote, M. G.; Chevalier, G.

In: Journal of Applied Toxicology, Vol. 6, No. 5, 1986, p. 317-323.

Research output: Contribution to journalArticle

Coulombe, PA, Lortie, S, Cote, MG & Chevalier, G 1986, 'Pulmonary toxicity of the insecticide fenitrothion in the rat following a single field exposure', Journal of Applied Toxicology, vol. 6, no. 5, pp. 317-323.
Coulombe, P. A. ; Lortie, S. ; Cote, M. G. ; Chevalier, G. / Pulmonary toxicity of the insecticide fenitrothion in the rat following a single field exposure. In: Journal of Applied Toxicology. 1986 ; Vol. 6, No. 5. pp. 317-323.
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