Pulmonary mucoepidermoid carcinoma with prominent tumor-associated lymphoid proliferation

Konstantin Shilo, Robert D. Foss, Teri J. Franks, Mariza DePeralta-Venturina, William D. Travis

Research output: Contribution to journalArticle

Abstract

We report 6 cases of low-grade pulmonary mucoepidermoid carcinoma displaying a striking lymphoplasmacytic infiltrate. All six tumors had a typical pulmonary mucoepidermoid carcinoma presentation as a polypoid endobronchial mass involving the proximal bronchi. The patients were 3 females and 3 males with a mean age of 33 years (range, 5-61 years). Half of the patients were asymptomatic, while half experienced mild symptoms of pneumonia, asthma-like symptoms, or hemoptysis. No tumor-related deaths were observed, with a mean follow-up of 51 months. The tumor size ranged from 2.1 to 3.4 cm (mean, 2.9 cm). The tumors characteristically displayed an elaborate tubulocystic epithelial component composed of intermediate, epidermoid, and mucus-producing cells, and variable numbers of clear cells, multinucleated giant cells, columnar cells, and oncocytic cells. The tumors' lymphoplasmacytic infiltrate with occasional Russell bodies was sufficiently intense to raise concern of a low-grade lymphoma. All tested tumors were immunoreactive with CK7 while nonreactive with TTF-1 and CK20. Recognition of this histologic variant is important for a correct diagnosis of low-grade pulmonary mucoepidermoid carcinoma. The dense lymphoplasmacytic infiltrate is similar to that previously described in salivary glands as tumor-associated lymphoid proliferation.

Original languageEnglish (US)
Pages (from-to)407-411
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume29
Issue number3
DOIs
StatePublished - Mar 2005
Externally publishedYes

Fingerprint

Mucoepidermoid Carcinoma
Lung
Neoplasms
Hemoptysis
Giant Cells
Bronchi
Mucus
Salivary Glands
Non-Hodgkin's Lymphoma
Pneumonia
Asthma
Cell Count

Keywords

  • Clear cells
  • Multinucleated giant cells
  • Pulmonary low-grade mucoepidermoid carcinoma
  • Tumor-associated lymphoid proliferation

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Pulmonary mucoepidermoid carcinoma with prominent tumor-associated lymphoid proliferation. / Shilo, Konstantin; Foss, Robert D.; Franks, Teri J.; DePeralta-Venturina, Mariza; Travis, William D.

In: American Journal of Surgical Pathology, Vol. 29, No. 3, 03.2005, p. 407-411.

Research output: Contribution to journalArticle

Shilo, Konstantin ; Foss, Robert D. ; Franks, Teri J. ; DePeralta-Venturina, Mariza ; Travis, William D. / Pulmonary mucoepidermoid carcinoma with prominent tumor-associated lymphoid proliferation. In: American Journal of Surgical Pathology. 2005 ; Vol. 29, No. 3. pp. 407-411.
@article{03ae8d22e23f4650af4583e1a6f6985d,
title = "Pulmonary mucoepidermoid carcinoma with prominent tumor-associated lymphoid proliferation",
abstract = "We report 6 cases of low-grade pulmonary mucoepidermoid carcinoma displaying a striking lymphoplasmacytic infiltrate. All six tumors had a typical pulmonary mucoepidermoid carcinoma presentation as a polypoid endobronchial mass involving the proximal bronchi. The patients were 3 females and 3 males with a mean age of 33 years (range, 5-61 years). Half of the patients were asymptomatic, while half experienced mild symptoms of pneumonia, asthma-like symptoms, or hemoptysis. No tumor-related deaths were observed, with a mean follow-up of 51 months. The tumor size ranged from 2.1 to 3.4 cm (mean, 2.9 cm). The tumors characteristically displayed an elaborate tubulocystic epithelial component composed of intermediate, epidermoid, and mucus-producing cells, and variable numbers of clear cells, multinucleated giant cells, columnar cells, and oncocytic cells. The tumors' lymphoplasmacytic infiltrate with occasional Russell bodies was sufficiently intense to raise concern of a low-grade lymphoma. All tested tumors were immunoreactive with CK7 while nonreactive with TTF-1 and CK20. Recognition of this histologic variant is important for a correct diagnosis of low-grade pulmonary mucoepidermoid carcinoma. The dense lymphoplasmacytic infiltrate is similar to that previously described in salivary glands as tumor-associated lymphoid proliferation.",
keywords = "Clear cells, Multinucleated giant cells, Pulmonary low-grade mucoepidermoid carcinoma, Tumor-associated lymphoid proliferation",
author = "Konstantin Shilo and Foss, {Robert D.} and Franks, {Teri J.} and Mariza DePeralta-Venturina and Travis, {William D.}",
year = "2005",
month = "3",
doi = "10.1097/01.pas.0000151616.14598.e7",
language = "English (US)",
volume = "29",
pages = "407--411",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Pulmonary mucoepidermoid carcinoma with prominent tumor-associated lymphoid proliferation

AU - Shilo, Konstantin

AU - Foss, Robert D.

AU - Franks, Teri J.

AU - DePeralta-Venturina, Mariza

AU - Travis, William D.

PY - 2005/3

Y1 - 2005/3

N2 - We report 6 cases of low-grade pulmonary mucoepidermoid carcinoma displaying a striking lymphoplasmacytic infiltrate. All six tumors had a typical pulmonary mucoepidermoid carcinoma presentation as a polypoid endobronchial mass involving the proximal bronchi. The patients were 3 females and 3 males with a mean age of 33 years (range, 5-61 years). Half of the patients were asymptomatic, while half experienced mild symptoms of pneumonia, asthma-like symptoms, or hemoptysis. No tumor-related deaths were observed, with a mean follow-up of 51 months. The tumor size ranged from 2.1 to 3.4 cm (mean, 2.9 cm). The tumors characteristically displayed an elaborate tubulocystic epithelial component composed of intermediate, epidermoid, and mucus-producing cells, and variable numbers of clear cells, multinucleated giant cells, columnar cells, and oncocytic cells. The tumors' lymphoplasmacytic infiltrate with occasional Russell bodies was sufficiently intense to raise concern of a low-grade lymphoma. All tested tumors were immunoreactive with CK7 while nonreactive with TTF-1 and CK20. Recognition of this histologic variant is important for a correct diagnosis of low-grade pulmonary mucoepidermoid carcinoma. The dense lymphoplasmacytic infiltrate is similar to that previously described in salivary glands as tumor-associated lymphoid proliferation.

AB - We report 6 cases of low-grade pulmonary mucoepidermoid carcinoma displaying a striking lymphoplasmacytic infiltrate. All six tumors had a typical pulmonary mucoepidermoid carcinoma presentation as a polypoid endobronchial mass involving the proximal bronchi. The patients were 3 females and 3 males with a mean age of 33 years (range, 5-61 years). Half of the patients were asymptomatic, while half experienced mild symptoms of pneumonia, asthma-like symptoms, or hemoptysis. No tumor-related deaths were observed, with a mean follow-up of 51 months. The tumor size ranged from 2.1 to 3.4 cm (mean, 2.9 cm). The tumors characteristically displayed an elaborate tubulocystic epithelial component composed of intermediate, epidermoid, and mucus-producing cells, and variable numbers of clear cells, multinucleated giant cells, columnar cells, and oncocytic cells. The tumors' lymphoplasmacytic infiltrate with occasional Russell bodies was sufficiently intense to raise concern of a low-grade lymphoma. All tested tumors were immunoreactive with CK7 while nonreactive with TTF-1 and CK20. Recognition of this histologic variant is important for a correct diagnosis of low-grade pulmonary mucoepidermoid carcinoma. The dense lymphoplasmacytic infiltrate is similar to that previously described in salivary glands as tumor-associated lymphoid proliferation.

KW - Clear cells

KW - Multinucleated giant cells

KW - Pulmonary low-grade mucoepidermoid carcinoma

KW - Tumor-associated lymphoid proliferation

UR - http://www.scopus.com/inward/record.url?scp=14644439210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14644439210&partnerID=8YFLogxK

U2 - 10.1097/01.pas.0000151616.14598.e7

DO - 10.1097/01.pas.0000151616.14598.e7

M3 - Article

C2 - 15725811

AN - SCOPUS:14644439210

VL - 29

SP - 407

EP - 411

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 3

ER -