Pulmonary metastases from uterine neoplasms after long tumour-free interval

Four cases and review of the literature

Hiroshi Miyamoto, Carolyn E. Jones, Daniel P. Raymond, John C. Wandtke, John G. Strang, Patricia A. Bourne, Thomas A. Bonfiglio, Haodong Xu

Research output: Contribution to journalArticle

Abstract

Aims: Uncommon cases of lung metastasis from different types of uterine neoplasms with a long tumour-free interval after hysterectomy are reported. Methods and results: Four cases were retrieved from our surgical pathology archives. Case 1 was a 68-year-old woman who had three pulmonary nodules 23 years after hysterectomy for low-grade endometrial stromal sarcoma LGESS. The nodules obtained with video-assisted thoracic surgeries were consistent with metastatic LGESS. Case 2 was a 36-year-old woman who had numerous bilateral pulmonary nodules 6 years after hysterectomy for leiomyoma. A transthoracic biopsy revealed benign metastasising leiomyoma. Case 3 was a 77-year-old woman who had a large lung mass with satellite nodules 17 years after hysterectomy with bilateral salpingo-oophorectomy and subsequent radiotherapy for endometrial endometrioid adenocarcinoma EEA. The biopsied and resected lung tumour was consistent with metastatic EEA. Case 4 was a 51-year-old woman who underwent total hysterectomy and subsequent radiotherapy for endocervical adenocarcinoma 12 years ago and lung lobectomy for metastatic disease 8 years ago. She then developed two pulmonary lesions 14 months ago, and these resected after radiotherapy were metastatic endocervical adenocarcinoma. Conclusions: A review of the literature revealed that late pulmonary metastasis from uterine neoplasms is rare but not negligible. Immunohistochemical studies and molecular tests, together with detailed clinical information and imaging findings, are important for rendering a diagnosis.

Original languageEnglish (US)
Pages (from-to)234-241
Number of pages8
JournalPathology
Volume41
Issue number3
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Uterine Neoplasms
Neoplasm Metastasis
Hysterectomy
Lung
Neoplasms
Radiotherapy
Leiomyoma
Adenocarcinoma
Endometrial Stromal Tumors
Endometrioid Carcinoma
Video-Assisted Thoracic Surgery
Surgical Pathology
Ovariectomy
Biopsy

Keywords

  • Benign metastasising leiomyoma
  • Endocervical adenocarcinoma
  • Endometrial endometrioid adenocarcinoma
  • Endometrial stromal sarcoma
  • Hysterectomy
  • Late recurrence
  • Lung
  • Metastasis
  • Uterus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Miyamoto, H., Jones, C. E., Raymond, D. P., Wandtke, J. C., Strang, J. G., Bourne, P. A., ... Xu, H. (2009). Pulmonary metastases from uterine neoplasms after long tumour-free interval: Four cases and review of the literature. Pathology, 41(3), 234-241. https://doi.org/10.1080/00313020902756238

Pulmonary metastases from uterine neoplasms after long tumour-free interval : Four cases and review of the literature. / Miyamoto, Hiroshi; Jones, Carolyn E.; Raymond, Daniel P.; Wandtke, John C.; Strang, John G.; Bourne, Patricia A.; Bonfiglio, Thomas A.; Xu, Haodong.

In: Pathology, Vol. 41, No. 3, 2009, p. 234-241.

Research output: Contribution to journalArticle

Miyamoto, H, Jones, CE, Raymond, DP, Wandtke, JC, Strang, JG, Bourne, PA, Bonfiglio, TA & Xu, H 2009, 'Pulmonary metastases from uterine neoplasms after long tumour-free interval: Four cases and review of the literature', Pathology, vol. 41, no. 3, pp. 234-241. https://doi.org/10.1080/00313020902756238
Miyamoto, Hiroshi ; Jones, Carolyn E. ; Raymond, Daniel P. ; Wandtke, John C. ; Strang, John G. ; Bourne, Patricia A. ; Bonfiglio, Thomas A. ; Xu, Haodong. / Pulmonary metastases from uterine neoplasms after long tumour-free interval : Four cases and review of the literature. In: Pathology. 2009 ; Vol. 41, No. 3. pp. 234-241.
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