Pulmonary metastases from autochthonous 3-methylcholanthrene-lnduced murine tumors

Hilda Wexler, Steven A. Rosenberg

Research output: Contribution to journalArticlepeer-review


In three experiments, 87%, 75%, and 85% of female C57BL/6N mice developed pulmonary metastases by 50 days after amputation of legs having autochthonous 3-methylcholan-threne-induced sarcomas. No difference in the incidence of pulmonary metastases was observed when autochthonous tumors of short (49-94 days) and longer (95-119 days) latency periods were compared. These metastasizing autochthonous tumors may provide a useful model for studies of metastases and for the evaluation of cancer therapy in a minimal residual disease setting.

Original languageEnglish (US)
Pages (from-to)1393-1395
Number of pages3
JournalJournal of the National Cancer Institute
Issue number6
StatePublished - Dec 1979

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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