Pulmonary metastases from a well differentiated giant cell tumor of bone. Report of a patient with apparent response to cyclophosphamide therapy

A. D. Kutchemeshgi, J. R. Wright, Richard L Humphrey

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The biologic behavior of giant cell tumors of bone cannot always be predicted from histologic appearance alone. In this case report, a histologically 'benign' giant cell tumor of the tibia metastasized to the lung, but over the course of 5 yr, exhibited little change in its well differentiated histologic appearance. Electron microscopy revealed ultrastructural features similar to those reported in clinically nonaggressive giant cell tumors. Control of pulmonary symptoms (pleuritic pain, hemoptysis) and stabilization of tumor growth followed the use of high dose cyclophosphamide. Although maintainance of a well differentiated appearace in the face of proven metastases is rare for this type of tumor, a number of similar examples have been recorded in the literature. As a rule, these patients enjoy a relatively favorable prognosis, when compared with those individuals in whom the metastases exhibit obvious sarcomatous dedifferentiation.

Original languageEnglish (US)
Title of host publicationJohns Hopkins Medical Journal
Pages237-245
Number of pages9
Volume134
Edition4
Publication statusPublished - 1974

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kutchemeshgi, A. D., Wright, J. R., & Humphrey, R. L. (1974). Pulmonary metastases from a well differentiated giant cell tumor of bone. Report of a patient with apparent response to cyclophosphamide therapy. In Johns Hopkins Medical Journal (4 ed., Vol. 134, pp. 237-245)