TY - JOUR
T1 - Pulmonary manifestations among patients with primary biliary cirrhosis
AU - Koksal, Deniz
AU - Koksal, Aydin Seref
AU - Gurakar, Ahmet
N1 - Publisher Copyright:
© 2016 The Second Affiliated Hospital of Chongqing Medical University.
PY - 2016
Y1 - 2016
N2 - Primary biliary cirrhosis (PBC) is a chronic progressive cho-lestatic liver disease caused by diffuse inflammation, destruc-tion and fibrosis of the intrahepatic bile ducts, ultimately leading to cirrhosis, portal hypertension and liver failure. The pathogenesis of PBC is incompletely understood, but current data suggest roles for genetic susceptibility and environmental factors. PBC is often thought of as an organ-specific autoimmune disease, which mainly targets the liver; how-ever, lung tissue is also a site for autoimmune involvement of PBC. The pulmonary manifestations of PBC include abnormalities in gas transfer and pulmonary function, subclinical alveolitis, interstitial lung disease, granulomatous lung dis-ease, airway disease, pulmonary hypertension, pulmonary hemorrhage and pleural effusion.
AB - Primary biliary cirrhosis (PBC) is a chronic progressive cho-lestatic liver disease caused by diffuse inflammation, destruc-tion and fibrosis of the intrahepatic bile ducts, ultimately leading to cirrhosis, portal hypertension and liver failure. The pathogenesis of PBC is incompletely understood, but current data suggest roles for genetic susceptibility and environmental factors. PBC is often thought of as an organ-specific autoimmune disease, which mainly targets the liver; how-ever, lung tissue is also a site for autoimmune involvement of PBC. The pulmonary manifestations of PBC include abnormalities in gas transfer and pulmonary function, subclinical alveolitis, interstitial lung disease, granulomatous lung dis-ease, airway disease, pulmonary hypertension, pulmonary hemorrhage and pleural effusion.
KW - Primary biliary cirrhosis
KW - Pulmonary functions
KW - Pulmonary involvement
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U2 - 10.14218/JCTH.2016.00024
DO - 10.14218/JCTH.2016.00024
M3 - Review article
AN - SCOPUS:85052731266
SN - 2225-0719
VL - 4
SP - 258
EP - 262
JO - Journal of Clinical and Translational Hepatology
JF - Journal of Clinical and Translational Hepatology
IS - 3
ER -