Pulmonary hypertension related to respiratory disease

Stephen Mathai, Reda E. Girgis

Research output: Contribution to journalArticle

Abstract

Cor pulmonale is a condition characterized by right ventricular hypertrophy, dilation, or both, occurring as a result of parenchymal lung disease, impaired respiratory neuromuscular mechanics, or altered ventilatory drive. Changes in right ventricular structure and function are a consequence of elevations in pulmonary arterial pressure and pulmonary vascular resistance, ie, pulmonary hypertension. Although alveolar hypoxia leading to pulmonary vasoconstriction may play an important role in the pathogenesis of pulmonary hypertension in respiratory disease, other mechanisms are likely to be involved. Recent studies have estimated that the prevalence of pulmonary hypertension complicating various forms of respiratory disease may be higher than previously thought. Although the magnitude of pulmonary arterial pressure elevation is often modest, the impact of pulmonary hypertension upon survival is significant. The role of pharmacologic agents approved for pulmonary arterial hypertension is yet to be defined. In this article, we (1) review the epidemiology and pathophysiology of pulmonary hypertension related to respiratory diseases, (2) outline recommendations for diagnostic evaluation, and (3) provide recommendations for therapy.

Original languageEnglish (US)
Pages (from-to)286-295
Number of pages10
JournalClinical Pulmonary Medicine
Volume14
Issue number5
DOIs
StatePublished - Sep 2007

Fingerprint

Pulmonary Hypertension
Lung
Arterial Pressure
Respiratory Mechanics
Right Ventricular Hypertrophy
Right Ventricular Function
Pulmonary Heart Disease
Vasoconstriction
Vascular Resistance
Lung Diseases
Dilatation
Epidemiology

Keywords

  • Chronic obstructive lung disease
  • Interstitial lung disease
  • Pulmonary hypertension
  • Respiratory diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Pulmonary hypertension related to respiratory disease. / Mathai, Stephen; Girgis, Reda E.

In: Clinical Pulmonary Medicine, Vol. 14, No. 5, 09.2007, p. 286-295.

Research output: Contribution to journalArticle

Mathai, Stephen ; Girgis, Reda E. / Pulmonary hypertension related to respiratory disease. In: Clinical Pulmonary Medicine. 2007 ; Vol. 14, No. 5. pp. 286-295.
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