Pulmonary hypertension and computed tomography measurement of small pulmonary vessels in severe emphysema

Shin Matsuoka, George R. Washko, Tsuneo Yamashiro, Raul San Jose Estepar, Alejandro Diaz, Edwin K. Silverman, Eric Hoffman, Henry Eric Fessler, Gerard J. Criner, Nathaniel Marchetti, Steven M. Scharf, Fernando J. Martinez, John J. Reilly, Hiroto Hatabu

Research output: Contribution to journalArticle

Abstract

Rationale: Vascular alteration of small pulmonary vessels is one of the characteristic features of pulmonary hypertension in chronic obstructive pulmonary disease. The in vivo relationship between pulmonary hypertension and morphological alteration of the small pulmonary vessels has not been assessed in patients with severe emphysema. Objectives:Weevaluatedthecorrelationof total cross-sectional areaof small pulmonary vessels (CSA) assessed on computed tomography (CT) scans with the degree of pulmonary hypertension estimated by right heart catheterization. Methods: In 79 patients with severe emphysema enrolled in the National Emphysema Treatment Trial (NETT), we measured CSA less than 5 mm2 (CSA) and 5 to 10 mm2 (CSA 5-10), and calculated the percentage of total CSA for the lung area (%CSA and %CSA5-10, respectively). The correlations of %CSA and %CSA5-10 with pulmonary arterial mean pressure (Ppacombining overline) obtained by right heart catheterization were evaluated. Multiple linear regression analysis using Ppacombining overline as the dependent outcome was also performed. Measurements and Main Results:The%CSA had a significant negative correlation with Ppacombining overline (r= -0.512, P5-10 and Ppa did not reach statistical significance (r = -0.196, P = 0.083). Multiple linear regression analysis showed that %CSA and diffusing capacity of carbon monoxide (DLCO) % predicted were independent predictors of Ppacombining overline (r2 = 0.541):%CSA (P <0.0001), and DLCO % predicted (P = 0.022). Conclusions: The %CSA measured on CT images is significantly correlated to Ppacombining overline in severe emphysema and can estimate the degree of pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)218-225
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume181
Issue number3
DOIs
StatePublished - Feb 1 2010

Fingerprint

Emphysema
Pulmonary Hypertension
Tomography
Lung
Cardiac Catheterization
Linear Models
Regression Analysis
Carbon Monoxide
Chronic Obstructive Pulmonary Disease
Blood Vessels
Arterial Pressure

Keywords

  • Chronic obstructive pulmonary disease
  • CT
  • Emphysema
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Pulmonary hypertension and computed tomography measurement of small pulmonary vessels in severe emphysema. / Matsuoka, Shin; Washko, George R.; Yamashiro, Tsuneo; Estepar, Raul San Jose; Diaz, Alejandro; Silverman, Edwin K.; Hoffman, Eric; Fessler, Henry Eric; Criner, Gerard J.; Marchetti, Nathaniel; Scharf, Steven M.; Martinez, Fernando J.; Reilly, John J.; Hatabu, Hiroto.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 181, No. 3, 01.02.2010, p. 218-225.

Research output: Contribution to journalArticle

Matsuoka, S, Washko, GR, Yamashiro, T, Estepar, RSJ, Diaz, A, Silverman, EK, Hoffman, E, Fessler, HE, Criner, GJ, Marchetti, N, Scharf, SM, Martinez, FJ, Reilly, JJ & Hatabu, H 2010, 'Pulmonary hypertension and computed tomography measurement of small pulmonary vessels in severe emphysema', American Journal of Respiratory and Critical Care Medicine, vol. 181, no. 3, pp. 218-225. https://doi.org/10.1164/rccm.200908-1189OC
Matsuoka, Shin ; Washko, George R. ; Yamashiro, Tsuneo ; Estepar, Raul San Jose ; Diaz, Alejandro ; Silverman, Edwin K. ; Hoffman, Eric ; Fessler, Henry Eric ; Criner, Gerard J. ; Marchetti, Nathaniel ; Scharf, Steven M. ; Martinez, Fernando J. ; Reilly, John J. ; Hatabu, Hiroto. / Pulmonary hypertension and computed tomography measurement of small pulmonary vessels in severe emphysema. In: American Journal of Respiratory and Critical Care Medicine. 2010 ; Vol. 181, No. 3. pp. 218-225.
@article{0f26276c2e504be7a4019c4153a1e021,
title = "Pulmonary hypertension and computed tomography measurement of small pulmonary vessels in severe emphysema",
abstract = "Rationale: Vascular alteration of small pulmonary vessels is one of the characteristic features of pulmonary hypertension in chronic obstructive pulmonary disease. The in vivo relationship between pulmonary hypertension and morphological alteration of the small pulmonary vessels has not been assessed in patients with severe emphysema. Objectives:Weevaluatedthecorrelationof total cross-sectional areaof small pulmonary vessels (CSA) assessed on computed tomography (CT) scans with the degree of pulmonary hypertension estimated by right heart catheterization. Methods: In 79 patients with severe emphysema enrolled in the National Emphysema Treatment Trial (NETT), we measured CSA less than 5 mm2 (CSA) and 5 to 10 mm2 (CSA 5-10), and calculated the percentage of total CSA for the lung area ({\%}CSA and {\%}CSA5-10, respectively). The correlations of {\%}CSA and {\%}CSA5-10 with pulmonary arterial mean pressure (Ppacombining overline) obtained by right heart catheterization were evaluated. Multiple linear regression analysis using Ppacombining overline as the dependent outcome was also performed. Measurements and Main Results:The{\%}CSA had a significant negative correlation with Ppacombining overline (r= -0.512, P5-10 and Ppa did not reach statistical significance (r = -0.196, P = 0.083). Multiple linear regression analysis showed that {\%}CSA and diffusing capacity of carbon monoxide (DLCO) {\%} predicted were independent predictors of Ppacombining overline (r2 = 0.541):{\%}CSA (P <0.0001), and DLCO {\%} predicted (P = 0.022). Conclusions: The {\%}CSA measured on CT images is significantly correlated to Ppacombining overline in severe emphysema and can estimate the degree of pulmonary hypertension.",
keywords = "Chronic obstructive pulmonary disease, CT, Emphysema, Pulmonary hypertension",
author = "Shin Matsuoka and Washko, {George R.} and Tsuneo Yamashiro and Estepar, {Raul San Jose} and Alejandro Diaz and Silverman, {Edwin K.} and Eric Hoffman and Fessler, {Henry Eric} and Criner, {Gerard J.} and Nathaniel Marchetti and Scharf, {Steven M.} and Martinez, {Fernando J.} and Reilly, {John J.} and Hiroto Hatabu",
year = "2010",
month = "2",
day = "1",
doi = "10.1164/rccm.200908-1189OC",
language = "English (US)",
volume = "181",
pages = "218--225",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "3",

}

TY - JOUR

T1 - Pulmonary hypertension and computed tomography measurement of small pulmonary vessels in severe emphysema

AU - Matsuoka, Shin

AU - Washko, George R.

AU - Yamashiro, Tsuneo

AU - Estepar, Raul San Jose

AU - Diaz, Alejandro

AU - Silverman, Edwin K.

AU - Hoffman, Eric

AU - Fessler, Henry Eric

AU - Criner, Gerard J.

AU - Marchetti, Nathaniel

AU - Scharf, Steven M.

AU - Martinez, Fernando J.

AU - Reilly, John J.

AU - Hatabu, Hiroto

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Rationale: Vascular alteration of small pulmonary vessels is one of the characteristic features of pulmonary hypertension in chronic obstructive pulmonary disease. The in vivo relationship between pulmonary hypertension and morphological alteration of the small pulmonary vessels has not been assessed in patients with severe emphysema. Objectives:Weevaluatedthecorrelationof total cross-sectional areaof small pulmonary vessels (CSA) assessed on computed tomography (CT) scans with the degree of pulmonary hypertension estimated by right heart catheterization. Methods: In 79 patients with severe emphysema enrolled in the National Emphysema Treatment Trial (NETT), we measured CSA less than 5 mm2 (CSA) and 5 to 10 mm2 (CSA 5-10), and calculated the percentage of total CSA for the lung area (%CSA and %CSA5-10, respectively). The correlations of %CSA and %CSA5-10 with pulmonary arterial mean pressure (Ppacombining overline) obtained by right heart catheterization were evaluated. Multiple linear regression analysis using Ppacombining overline as the dependent outcome was also performed. Measurements and Main Results:The%CSA had a significant negative correlation with Ppacombining overline (r= -0.512, P5-10 and Ppa did not reach statistical significance (r = -0.196, P = 0.083). Multiple linear regression analysis showed that %CSA and diffusing capacity of carbon monoxide (DLCO) % predicted were independent predictors of Ppacombining overline (r2 = 0.541):%CSA (P <0.0001), and DLCO % predicted (P = 0.022). Conclusions: The %CSA measured on CT images is significantly correlated to Ppacombining overline in severe emphysema and can estimate the degree of pulmonary hypertension.

AB - Rationale: Vascular alteration of small pulmonary vessels is one of the characteristic features of pulmonary hypertension in chronic obstructive pulmonary disease. The in vivo relationship between pulmonary hypertension and morphological alteration of the small pulmonary vessels has not been assessed in patients with severe emphysema. Objectives:Weevaluatedthecorrelationof total cross-sectional areaof small pulmonary vessels (CSA) assessed on computed tomography (CT) scans with the degree of pulmonary hypertension estimated by right heart catheterization. Methods: In 79 patients with severe emphysema enrolled in the National Emphysema Treatment Trial (NETT), we measured CSA less than 5 mm2 (CSA) and 5 to 10 mm2 (CSA 5-10), and calculated the percentage of total CSA for the lung area (%CSA and %CSA5-10, respectively). The correlations of %CSA and %CSA5-10 with pulmonary arterial mean pressure (Ppacombining overline) obtained by right heart catheterization were evaluated. Multiple linear regression analysis using Ppacombining overline as the dependent outcome was also performed. Measurements and Main Results:The%CSA had a significant negative correlation with Ppacombining overline (r= -0.512, P5-10 and Ppa did not reach statistical significance (r = -0.196, P = 0.083). Multiple linear regression analysis showed that %CSA and diffusing capacity of carbon monoxide (DLCO) % predicted were independent predictors of Ppacombining overline (r2 = 0.541):%CSA (P <0.0001), and DLCO % predicted (P = 0.022). Conclusions: The %CSA measured on CT images is significantly correlated to Ppacombining overline in severe emphysema and can estimate the degree of pulmonary hypertension.

KW - Chronic obstructive pulmonary disease

KW - CT

KW - Emphysema

KW - Pulmonary hypertension

UR - http://www.scopus.com/inward/record.url?scp=76749108665&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76749108665&partnerID=8YFLogxK

U2 - 10.1164/rccm.200908-1189OC

DO - 10.1164/rccm.200908-1189OC

M3 - Article

VL - 181

SP - 218

EP - 225

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 3

ER -