Pulmonary hyperinflation and left ventricular mass

The multi-ethnic study of atherosclerosis COPD study

Benjamin M. Smith, Steven M. Kawut, David A. Bluemke, Robert C. Basner, Antoinette S. Gomes, Eric Hoffman, Ravi Kalhan, Joao Lima, Chia Ying Liu, Erin Donnelly Michos, Martin R. Prince, Leroy Rabbani, Daniel Rabinowitz, Daichi Shimbo, Steven Shea, R. Graham Barr

Research output: Contribution to journalArticle

Abstract

Background-Left ventricular (LV) mass is an important predictor of heart failure and cardiovascular mortality, yet determinants of LV mass are incompletely understood. Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) may contribute to changes in intrathoracic pressure that increase LV wall stress. We therefore hypothesized that residual lung volume in COPD would be associated with greater LV mass. Methods and Results-The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited smokers 50 to 79 years of age who were free of clinical cardiovascular disease. LV mass was measured by cardiac magnetic resonance. Pulmonary function testing was performed according to guidelines. Regression models were used to adjust for age, sex, body size, blood pressure, and other cardiac risk factors. Among 119 MESA COPD Study participants, the mean age was 69±6 years, 55% were male, and 65% had COPD, mostly of mild or moderate severity. Mean LV mass was 128±34 g. Residual lung volume was independently associated with greater LV mass (7.2 g per 1-SD increase in residual volume; 95% confidence interval, 2.2-12; P=0.004) and was similar in magnitude to that of systolic blood pressure (7.6 g per 1-SD increase in systolic blood pressure; 95% confidence interval, 4.3-11; P

Original languageEnglish (US)
Pages (from-to)1503-1511
Number of pages9
JournalCirculation
Volume127
Issue number14
DOIs
StatePublished - Apr 9 2013

Fingerprint

Chronic Obstructive Pulmonary Disease
Atherosclerosis
Residual Volume
Blood Pressure
Lung
Confidence Intervals
Body Size
Cardiovascular Diseases
Magnetic Resonance Spectroscopy
Heart Failure
Guidelines
Pressure
Mortality

Keywords

  • Chronic obstructive pulmonary disease
  • Hyperinflation
  • Left ventricular mass

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Smith, B. M., Kawut, S. M., Bluemke, D. A., Basner, R. C., Gomes, A. S., Hoffman, E., ... Barr, R. G. (2013). Pulmonary hyperinflation and left ventricular mass: The multi-ethnic study of atherosclerosis COPD study. Circulation, 127(14), 1503-1511. https://doi.org/10.1161/CIRCULATIONAHA.113.001653

Pulmonary hyperinflation and left ventricular mass : The multi-ethnic study of atherosclerosis COPD study. / Smith, Benjamin M.; Kawut, Steven M.; Bluemke, David A.; Basner, Robert C.; Gomes, Antoinette S.; Hoffman, Eric; Kalhan, Ravi; Lima, Joao; Liu, Chia Ying; Michos, Erin Donnelly; Prince, Martin R.; Rabbani, Leroy; Rabinowitz, Daniel; Shimbo, Daichi; Shea, Steven; Barr, R. Graham.

In: Circulation, Vol. 127, No. 14, 09.04.2013, p. 1503-1511.

Research output: Contribution to journalArticle

Smith, BM, Kawut, SM, Bluemke, DA, Basner, RC, Gomes, AS, Hoffman, E, Kalhan, R, Lima, J, Liu, CY, Michos, ED, Prince, MR, Rabbani, L, Rabinowitz, D, Shimbo, D, Shea, S & Barr, RG 2013, 'Pulmonary hyperinflation and left ventricular mass: The multi-ethnic study of atherosclerosis COPD study', Circulation, vol. 127, no. 14, pp. 1503-1511. https://doi.org/10.1161/CIRCULATIONAHA.113.001653
Smith, Benjamin M. ; Kawut, Steven M. ; Bluemke, David A. ; Basner, Robert C. ; Gomes, Antoinette S. ; Hoffman, Eric ; Kalhan, Ravi ; Lima, Joao ; Liu, Chia Ying ; Michos, Erin Donnelly ; Prince, Martin R. ; Rabbani, Leroy ; Rabinowitz, Daniel ; Shimbo, Daichi ; Shea, Steven ; Barr, R. Graham. / Pulmonary hyperinflation and left ventricular mass : The multi-ethnic study of atherosclerosis COPD study. In: Circulation. 2013 ; Vol. 127, No. 14. pp. 1503-1511.
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