Pulmonary embolization of bovine collagen.

Denis M. McCarthy, Mark Haas, Paul J. Thuluvath, Jeff F. Geschwind, Grover M. Hutchins, William H. Westra

Research output: Contribution to journalArticle

Abstract

A bovine collagen matrix is sometimes used as a delivery medium during direct intratumoral injection of a chemotherapeutic agent. The bovine collagen enhances the dose and duration of local drug delivery and limits systemic toxicity. Although this strategy is advocated as a means of easy and effective delivery of chemotherapeutic drugs, the associated risks are not well defined. We report the case of a 71-year-old man with hepatocellular carcinoma who underwent weekly intratumoral injections of cisplatin in a bovine collagen matrix. During the third injection, he suddenly and unexpectedly underwent cardiac arrest and died. An autopsy disclosed diffuse occlusion of the pulmonary microcirculation by bovine collagen. The collagen emboli were associated with an inflammatory infiltrate typical of bovine collagen-induced hypersensitivity. This case identifies a fatal complication of intratumoral chemotherapy injections using a bovine collagen matrix, which does not appear to have been previously reported. This case underscores the valuable role of the traditional autopsy examination as a means of identifying possible complications of novel oncologic strategies, which are being rapidly developed and implemented.

Original languageEnglish (US)
JournalArchives of Pathology and Laboratory Medicine
Volume127
Issue number2
StatePublished - 2003

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Collagen
Lung
Injections
Autopsy
Microcirculation
Heart Arrest
Embolism
Pharmaceutical Preparations
Cisplatin
Hepatocellular Carcinoma
Hypersensitivity
Drug Therapy

Cite this

McCarthy, D. M., Haas, M., Thuluvath, P. J., Geschwind, J. F., Hutchins, G. M., & Westra, W. H. (2003). Pulmonary embolization of bovine collagen. Archives of Pathology and Laboratory Medicine, 127(2).

Pulmonary embolization of bovine collagen. / McCarthy, Denis M.; Haas, Mark; Thuluvath, Paul J.; Geschwind, Jeff F.; Hutchins, Grover M.; Westra, William H.

In: Archives of Pathology and Laboratory Medicine, Vol. 127, No. 2, 2003.

Research output: Contribution to journalArticle

McCarthy, DM, Haas, M, Thuluvath, PJ, Geschwind, JF, Hutchins, GM & Westra, WH 2003, 'Pulmonary embolization of bovine collagen.', Archives of Pathology and Laboratory Medicine, vol. 127, no. 2.
McCarthy DM, Haas M, Thuluvath PJ, Geschwind JF, Hutchins GM, Westra WH. Pulmonary embolization of bovine collagen. Archives of Pathology and Laboratory Medicine. 2003;127(2).
McCarthy, Denis M. ; Haas, Mark ; Thuluvath, Paul J. ; Geschwind, Jeff F. ; Hutchins, Grover M. ; Westra, William H. / Pulmonary embolization of bovine collagen. In: Archives of Pathology and Laboratory Medicine. 2003 ; Vol. 127, No. 2.
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