Pulmonary dysfunction in pediatric hematopoietic stem cell transplant patients: Overview, diagnostic considerations, and infectious complications

Research output: Contribution to journalReview articlepeer-review

Abstract

Pulmonary complications are among the most common and serious sequelae seen in hematopoietic stem cell transplantation (HSCT) recipients. This two-part review addresses the incidence and impact of pulmonary complications in pediatric HSCT patients. In this first part we review the available data for the use of diagnostic modalities in this population, including flexible bronchoscopy with bronchoalveolar lavage (BAL) and open lung biopsy (OLB). We also review the many infectious pulmonary complications that may occur in pediatric HSCT recipients, utilizing the traditional chronologic divisions of neutropenic phase (0-30 days following HSCT), early phase (30-100 days), and late phase (>100 days).

Original languageEnglish (US)
Pages (from-to)117-126
Number of pages10
JournalPediatric Blood and Cancer
Volume49
Issue number2
DOIs
StatePublished - Aug 1 2007

Keywords

  • Bone marrow transplant (BMT)
  • Hematopoietic stem cell transplant (HSCT)
  • Infection
  • Pediatric
  • Pneumonia
  • Pneumonitis
  • Pulmonary complications

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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