Pulmonary disease associated with pleural 'asbestos' plaques

R. F. Sison, R. H. Hruban, G. W. Moore, J. E. Kuhlman, P. S. Wheeler, G. M. Hutchins

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The diagnosis of asbestos-related pulmonary disease is frequently based in part on the identification of pleural plaques; however, postmorten observations have suggested that pleural plaques may occur without associated pulmonary disease. To examine this issue, we compared the pulmonary parenchymal pathology in 93 patients with pleural plaques to 93 control patients matched for age, race, and sex, all autopsied at The Johns Hopkins Hospital between Jan 1, 1981 and March 31, 1986. Pulmonary sections were graded without knowledge of the patient's group for peribronchial fibrosis, other types of fibrosis, emphysema, and pleural changes. Correlations were found between the presence of pleural plaques and peribronchiolar fibrosis (p < 0.001), alveolar fibrosis (p < 0.05), large scars (p < 0.02), scar-related emphysema (p < 0.02), and pleural thickening (p < 0.005). A history of smoking was also associated with pleural plaques (p < 0.05). Interstitial fibrosis was not significantly different between the two groups. Peribronchiolar fibrosis was neither universally nor exclusively present in patients with pleural plaques, being found in 49 (53 percent) of 93 subjects with and 36 (39 percent) of 93 subjects without plaques. The results suggest that caution must be exercised in extrapolating from the identification of pleural plaques to a diagnosis of asbestos-related pulmonary disease.

Original languageEnglish (US)
Pages (from-to)831-835
Number of pages5
Issue number4
StatePublished - 1989

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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