Pulmonary Complications of Pediatric Hematopoietic Cell Transplantation A National Institutes of Health Workshop Summary

Robert F. Tamburro, Kenneth R. Cooke, Stella M. Davies, Samuel Goldfarb, James S. Hagood, Ashok Srinivasan, Marie E. Steiner, Dennis Stokes, Nancy DiFronzo, Nahed El-Kassar, Nonniekaye Shelburne, Aruna Natarajan

Research output: Contribution to journalArticlepeer-review

Abstract

Approximately 2,500 pediatric hematopoietic cell transplants (HCTs), most of which are allogeneic, are performed annually in the United States for life-threatening malignant and nonmalignant conditions. Although HCT is undertaken with curative intent, post-HCT complications limit successful outcomes, with pulmonary dysfunction representing the leading cause of nonrelapse mortality. To better understand, predict, prevent, and/or treat pulmonary complications after HCT, a multidisciplinary group of 33 experts met in a 2-day National Institutes of Health Workshop to identify knowledge gaps and research strategies most likely to improve outcomes. This summary of Workshop deliberations outlines the consensus focus areas for future research.

Original languageEnglish (US)
Pages (from-to)381-394
Number of pages14
JournalAnnals of the American Thoracic Society
Volume18
Issue number3
DOIs
StatePublished - Mar 2021

Keywords

  • Acute respiratory distress syndrome
  • Hematopoietic cell transplantation
  • Pediatrics
  • Pulmonary complications
  • Respiratory failure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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