Pulmonary blood flow affects recovery from constriction in dog lung periphery

L. J. Kelly, Wayne A Mitzner, Ernst W Spannhake, B. Bromberger-Barnea, H. A. Menkes

Research output: Contribution to journalArticle

Abstract

The influence of blood flow through the pulmonary circulation on the time course of recovery of the lung periphery from challenge with three bronchoconstrictive agents was studied in dogs. The rate of perfusion of the left lower lobe was varied between 0 and 300 ml/min. A fiber-optic bronchoscope (OD = 5.5 mm) was wedged in a small airway in the same lobe, and resistance to airflow through the collateral system was continuously monitored. The lung was challenged with histamine aerosol for 1 min, or with intravenous boluses of histamine, acetylcholine, or methacholine. The time constant (τ) of recovery from each of the challenges was measured under the various pulmonary blood flow conditions. The mean τ of the recoveries from histamine was inversely related to the rate of blood flow. However, pulmonary blood flow had no effect on recovery from challenge with acetylcholine or methacholine, two agents metabolized by cholinesterase in lung tissue. From this study we conclude that recovery of the lung periphery from histamine is perfusion dependent, whereas recovery from acetylcholine or metacholine is perfusion independent. This suggests that the rate of blood flow through the pulmonary circulation could play an important role in recovery of the peripheral airways from certain mediators of bronchoconstriction.

Original languageEnglish (US)
Pages (from-to)1554-1560
Number of pages7
JournalJournal of Applied Physiology
Volume60
Issue number5
StatePublished - 1986

Fingerprint

Constriction
Dogs
Lung
Histamine
Acetylcholine
Pulmonary Circulation
Methacholine Chloride
Perfusion
Bronchoscopes
Myelinated Nerve Fibers
Bronchoconstriction
Cholinesterases
Aerosols

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Pulmonary blood flow affects recovery from constriction in dog lung periphery. / Kelly, L. J.; Mitzner, Wayne A; Spannhake, Ernst W; Bromberger-Barnea, B.; Menkes, H. A.

In: Journal of Applied Physiology, Vol. 60, No. 5, 1986, p. 1554-1560.

Research output: Contribution to journalArticle

Kelly, L. J. ; Mitzner, Wayne A ; Spannhake, Ernst W ; Bromberger-Barnea, B. ; Menkes, H. A. / Pulmonary blood flow affects recovery from constriction in dog lung periphery. In: Journal of Applied Physiology. 1986 ; Vol. 60, No. 5. pp. 1554-1560.
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