Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema

The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study

Chia Ying Liu, Megha Parikh, David A. Bluemke, Pallavi Balte, James Carr, Stephen Dashnaw, Hooman D. Poor, Antoinette S. Gomes, Eric A. Hoffman, Steven M. Kawut, Joao Lima, David A. Mcallister, Martin A. Prince, Jens Vogel-Claussen, R. Graham Barr

Research output: Contribution to journalArticle

Abstract

Purpose: Chronic obstructive pulmonary disease (COPD) and particularly emphysema are characterized by stiffness of the aorta, due in part to accelerated elastin degradation in the lungs and aorta. Stiffness of the pulmonary arteries (PAs) may also be increased in COPD and emphysema, but data are lacking. We assessed PA stiffness using MRI in patients with COPD and related these measurements to COPD severity and percent emphysema. Materials and Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited 290 participants, age 50-79 years with 10 or more packyears and free of clinical cardiovascular disease. COPD severity were defined on postbronchodilator spirometry by ATS/ERS criteria. Percent emphysema was defined as the percentage of regions of the lung < -950 Hounsfield units on full-lung computed tomography (CT). PA stain was defined by the percent change in cross-sectional PA area between systole and diastole on MRI. Blood flow across the tricuspid and mitral valves was assessed by phase-contrast MRI for determination of the ventricular diastolic dysfunction (E/A ratio). Results: PA strain was reduced in COPD compared with controls (P = 0.002) and was inversely correlated with COPD severity (P = 0.004). PA strain was inversely associated to percent emphysema (P = 0.01). PA strain was also markedly correlated with right ventricular diastolic dysfunction measured by E/A ratios in the fully adjusted mix models (P = 0.02). Conclusion: PA strain is reduced in COPD, related in part to percent emphysema on CT scan, which may have implications for pulmonary small vessel flow and right ventricular function.

Original languageEnglish (US)
JournalJournal of Magnetic Resonance Imaging
DOIs
StateAccepted/In press - 2017

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Pulmonary Emphysema
Chronic Obstructive Pulmonary Disease
Pulmonary Artery
Atherosclerosis
Emphysema
Lung
Aorta
Tomography
Right Ventricular Dysfunction
Ventricular Dysfunction
Right Ventricular Function
Tricuspid Valve
Diastole
Elastin
Systole
Spirometry
Mitral Valve
Coloring Agents
Cardiovascular Diseases

Keywords

  • Lung function/COPD
  • MR flowing imaging
  • Pulmonary artery
  • Strain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema : The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study. / Liu, Chia Ying; Parikh, Megha; Bluemke, David A.; Balte, Pallavi; Carr, James; Dashnaw, Stephen; Poor, Hooman D.; Gomes, Antoinette S.; Hoffman, Eric A.; Kawut, Steven M.; Lima, Joao; Mcallister, David A.; Prince, Martin A.; Vogel-Claussen, Jens; Barr, R. Graham.

In: Journal of Magnetic Resonance Imaging, 2017.

Research output: Contribution to journalArticle

Liu, CY, Parikh, M, Bluemke, DA, Balte, P, Carr, J, Dashnaw, S, Poor, HD, Gomes, AS, Hoffman, EA, Kawut, SM, Lima, J, Mcallister, DA, Prince, MA, Vogel-Claussen, J & Barr, RG 2017, 'Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study', Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.25753
Liu, Chia Ying ; Parikh, Megha ; Bluemke, David A. ; Balte, Pallavi ; Carr, James ; Dashnaw, Stephen ; Poor, Hooman D. ; Gomes, Antoinette S. ; Hoffman, Eric A. ; Kawut, Steven M. ; Lima, Joao ; Mcallister, David A. ; Prince, Martin A. ; Vogel-Claussen, Jens ; Barr, R. Graham. / Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema : The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study. In: Journal of Magnetic Resonance Imaging. 2017.
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abstract = "Purpose: Chronic obstructive pulmonary disease (COPD) and particularly emphysema are characterized by stiffness of the aorta, due in part to accelerated elastin degradation in the lungs and aorta. Stiffness of the pulmonary arteries (PAs) may also be increased in COPD and emphysema, but data are lacking. We assessed PA stiffness using MRI in patients with COPD and related these measurements to COPD severity and percent emphysema. Materials and Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited 290 participants, age 50-79 years with 10 or more packyears and free of clinical cardiovascular disease. COPD severity were defined on postbronchodilator spirometry by ATS/ERS criteria. Percent emphysema was defined as the percentage of regions of the lung < -950 Hounsfield units on full-lung computed tomography (CT). PA stain was defined by the percent change in cross-sectional PA area between systole and diastole on MRI. Blood flow across the tricuspid and mitral valves was assessed by phase-contrast MRI for determination of the ventricular diastolic dysfunction (E/A ratio). Results: PA strain was reduced in COPD compared with controls (P = 0.002) and was inversely correlated with COPD severity (P = 0.004). PA strain was inversely associated to percent emphysema (P = 0.01). PA strain was also markedly correlated with right ventricular diastolic dysfunction measured by E/A ratios in the fully adjusted mix models (P = 0.02). Conclusion: PA strain is reduced in COPD, related in part to percent emphysema on CT scan, which may have implications for pulmonary small vessel flow and right ventricular function.",
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T1 - Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema

T2 - The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study

AU - Liu, Chia Ying

AU - Parikh, Megha

AU - Bluemke, David A.

AU - Balte, Pallavi

AU - Carr, James

AU - Dashnaw, Stephen

AU - Poor, Hooman D.

AU - Gomes, Antoinette S.

AU - Hoffman, Eric A.

AU - Kawut, Steven M.

AU - Lima, Joao

AU - Mcallister, David A.

AU - Prince, Martin A.

AU - Vogel-Claussen, Jens

AU - Barr, R. Graham

PY - 2017

Y1 - 2017

N2 - Purpose: Chronic obstructive pulmonary disease (COPD) and particularly emphysema are characterized by stiffness of the aorta, due in part to accelerated elastin degradation in the lungs and aorta. Stiffness of the pulmonary arteries (PAs) may also be increased in COPD and emphysema, but data are lacking. We assessed PA stiffness using MRI in patients with COPD and related these measurements to COPD severity and percent emphysema. Materials and Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited 290 participants, age 50-79 years with 10 or more packyears and free of clinical cardiovascular disease. COPD severity were defined on postbronchodilator spirometry by ATS/ERS criteria. Percent emphysema was defined as the percentage of regions of the lung < -950 Hounsfield units on full-lung computed tomography (CT). PA stain was defined by the percent change in cross-sectional PA area between systole and diastole on MRI. Blood flow across the tricuspid and mitral valves was assessed by phase-contrast MRI for determination of the ventricular diastolic dysfunction (E/A ratio). Results: PA strain was reduced in COPD compared with controls (P = 0.002) and was inversely correlated with COPD severity (P = 0.004). PA strain was inversely associated to percent emphysema (P = 0.01). PA strain was also markedly correlated with right ventricular diastolic dysfunction measured by E/A ratios in the fully adjusted mix models (P = 0.02). Conclusion: PA strain is reduced in COPD, related in part to percent emphysema on CT scan, which may have implications for pulmonary small vessel flow and right ventricular function.

AB - Purpose: Chronic obstructive pulmonary disease (COPD) and particularly emphysema are characterized by stiffness of the aorta, due in part to accelerated elastin degradation in the lungs and aorta. Stiffness of the pulmonary arteries (PAs) may also be increased in COPD and emphysema, but data are lacking. We assessed PA stiffness using MRI in patients with COPD and related these measurements to COPD severity and percent emphysema. Materials and Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited 290 participants, age 50-79 years with 10 or more packyears and free of clinical cardiovascular disease. COPD severity were defined on postbronchodilator spirometry by ATS/ERS criteria. Percent emphysema was defined as the percentage of regions of the lung < -950 Hounsfield units on full-lung computed tomography (CT). PA stain was defined by the percent change in cross-sectional PA area between systole and diastole on MRI. Blood flow across the tricuspid and mitral valves was assessed by phase-contrast MRI for determination of the ventricular diastolic dysfunction (E/A ratio). Results: PA strain was reduced in COPD compared with controls (P = 0.002) and was inversely correlated with COPD severity (P = 0.004). PA strain was inversely associated to percent emphysema (P = 0.01). PA strain was also markedly correlated with right ventricular diastolic dysfunction measured by E/A ratios in the fully adjusted mix models (P = 0.02). Conclusion: PA strain is reduced in COPD, related in part to percent emphysema on CT scan, which may have implications for pulmonary small vessel flow and right ventricular function.

KW - Lung function/COPD

KW - MR flowing imaging

KW - Pulmonary artery

KW - Strain

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DO - 10.1002/jmri.25753

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