PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate

Tao Qiu, Lingling Xian, Janet Crane, Chunyi Wen, Matthew Hilton, William Lu, Peter Newman, Xu Cao

Research output: Contribution to journalArticlepeer-review

Abstract

Longitudinal growth of postnatal bone requires precise control of growth plate cartilage chondrocytes and subsequent osteogenesis and bone formation. Little is known about the role of angiogenesis and bone remodeling in maintenance of cartilaginous growth plate. Parathyroid hormone (PTH) stimulates bone remodeling by activating PTH receptor (PTH1R). Mice with conditional deletion of PTH1R in osteoblasts showed disrupted trabecular bone formation. The mice also exhibited postnatal growth retardation with profound defects in growth plate cartilage, ascribable predominantly to a decrease in number of hypertrophic chondrocytes, resulting in premature fusion of the growth plate and shortened long bones. Further characterization of hypertrophic zone and primary spongiosa revealed that endochondral angiogenesis and vascular invasion of the cartilage were impaired, which was associated with aberrant chondrocyte maturation and cartilage development. These studies reveal that PTH1R signaling in osteoblasts regulates cartilaginous growth plate for postnatal growth of bone.

Original languageEnglish (US)
Pages (from-to)309-317
Number of pages9
JournalJournal of Bone and Mineral Research
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • Growth plate
  • Parathyroid hormone
  • Postnatal bone growth
  • Vascularization

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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