Psychosis and genes with trinucleotide repeat polymorphism

Tsukasa Sasaki, Elizabeth Billett, Arturas Petronis, Dajun Ying, Thomas Parsons, Fabio M. Macciardi, Herbert Y. Meltzer, Jeffrey Lieberman, Russel T. Joffe, Christopher A Ross, Melvin G. McInnis, Shi Hua Li, James L. Kennedy

Research output: Contribution to journalArticle

Abstract

Abnormal expansion of genes with trinucleotide repeat (TNR) polymorphism has been found in a number of neuropsychiatric disorders. These disorders and the major psychoses, schizophrenia and bipolar affective disorder, appear to share an interesting phenomenon: genetic anticipation. Because TNR expansion correlates with anticipation, these unstable DNA sites are considered important candidate loci for the major psychoses. We investigated genes with TNR polymorphisms, including B1, B33, B37, and the N-cadherin gene, in unrelated Caucasian North American and Italian schizophrenics (n = 53 to 74), and matched controls. Also, unrelated Caucasian North American patients with bipolar I affective disorder were screened for the B33 and N-cadherin genes (n = 49 and 63, respectively). No unusually long alleles that would suggest abnormal expansion of the TNR were observed for any of these genes. Also, no statistically significant results were found in tests for genetic association between any of these genes and schizophrenia. For B37, a trend toward a difference in allele counts between schizophrenics and controls was observed. However, no clear evidence for a role of these TNR-containing genes in schizophrenia or bipolar affective disorders was found.

Original languageEnglish (US)
Pages (from-to)244-246
Number of pages3
JournalHuman Genetics
Volume97
Issue number2
DOIs
StatePublished - Feb 1996

Fingerprint

Trinucleotide Repeats
Psychotic Disorders
Genes
Mood Disorders
Trinucleotide Repeat Expansion
Schizophrenia
Cadherins
Bipolar Disorder
Genetic Anticipation
Alleles
DNA

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Sasaki, T., Billett, E., Petronis, A., Ying, D., Parsons, T., Macciardi, F. M., ... Kennedy, J. L. (1996). Psychosis and genes with trinucleotide repeat polymorphism. Human Genetics, 97(2), 244-246. https://doi.org/10.1007/BF02265274

Psychosis and genes with trinucleotide repeat polymorphism. / Sasaki, Tsukasa; Billett, Elizabeth; Petronis, Arturas; Ying, Dajun; Parsons, Thomas; Macciardi, Fabio M.; Meltzer, Herbert Y.; Lieberman, Jeffrey; Joffe, Russel T.; Ross, Christopher A; McInnis, Melvin G.; Li, Shi Hua; Kennedy, James L.

In: Human Genetics, Vol. 97, No. 2, 02.1996, p. 244-246.

Research output: Contribution to journalArticle

Sasaki, T, Billett, E, Petronis, A, Ying, D, Parsons, T, Macciardi, FM, Meltzer, HY, Lieberman, J, Joffe, RT, Ross, CA, McInnis, MG, Li, SH & Kennedy, JL 1996, 'Psychosis and genes with trinucleotide repeat polymorphism', Human Genetics, vol. 97, no. 2, pp. 244-246. https://doi.org/10.1007/BF02265274
Sasaki T, Billett E, Petronis A, Ying D, Parsons T, Macciardi FM et al. Psychosis and genes with trinucleotide repeat polymorphism. Human Genetics. 1996 Feb;97(2):244-246. https://doi.org/10.1007/BF02265274
Sasaki, Tsukasa ; Billett, Elizabeth ; Petronis, Arturas ; Ying, Dajun ; Parsons, Thomas ; Macciardi, Fabio M. ; Meltzer, Herbert Y. ; Lieberman, Jeffrey ; Joffe, Russel T. ; Ross, Christopher A ; McInnis, Melvin G. ; Li, Shi Hua ; Kennedy, James L. / Psychosis and genes with trinucleotide repeat polymorphism. In: Human Genetics. 1996 ; Vol. 97, No. 2. pp. 244-246.
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