Psychophysics of Sensations Evoked by Stimulation of the Human Central Nervous System

S. Ohara, C. A. Bagley, H. C. Lawson, Frederick Lenz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The forebrain neuronal system signaling pain has been poorly characterized. We now show that stimulation of thalamic pain-related nuclei in awake humans produces two different responses. The first is a binary response in which a constant painful sensation is evoked regardless of the pattern of stimulation. The second is an analog response in which nonpainful and painful sensations are graded with intensity of the stimulus, and are better defined than the first, both qualitatively and spatially. These results are consistent with those of functional imaging studies that have identified brain regions activated in a binary fashion by a particular stimulus, while further increases in stimulus intensity do not produce increased activation. Binary response sites may participate in all or none attentional or cognitive aspects of pain. Stimulation of these thalamic regions may also mediate memories of the emotional aspect of intense pain and of chronic pain that sometimes results from intense pains. These pain memories are not evoked by stimulation of the spinothalamic tract, which suggests that they involve conditioning of forebrain structures, rather than simple activation of these structures by a painful stimulus.

Original languageEnglish (US)
Title of host publicationThe Senses: A Comprehensive Reference
PublisherElsevier Inc.
Pages655-668
Number of pages14
Volume5
ISBN (Print)9780123708809
DOIs
StatePublished - 2010

Fingerprint

Psychophysics
Central Nervous System
Pain
Prosencephalon
Spinothalamic Tracts
Chronic Pain
Brain

Keywords

  • Human
  • Memories
  • Microstimulation
  • Pain
  • Principal sensory nucleus of thalamus
  • Thalamic ventral posterior nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ohara, S., Bagley, C. A., Lawson, H. C., & Lenz, F. (2010). Psychophysics of Sensations Evoked by Stimulation of the Human Central Nervous System. In The Senses: A Comprehensive Reference (Vol. 5, pp. 655-668). Elsevier Inc.. https://doi.org/10.1016/B978-012370880-9.00186-9

Psychophysics of Sensations Evoked by Stimulation of the Human Central Nervous System. / Ohara, S.; Bagley, C. A.; Lawson, H. C.; Lenz, Frederick.

The Senses: A Comprehensive Reference. Vol. 5 Elsevier Inc., 2010. p. 655-668.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ohara, S, Bagley, CA, Lawson, HC & Lenz, F 2010, Psychophysics of Sensations Evoked by Stimulation of the Human Central Nervous System. in The Senses: A Comprehensive Reference. vol. 5, Elsevier Inc., pp. 655-668. https://doi.org/10.1016/B978-012370880-9.00186-9
Ohara S, Bagley CA, Lawson HC, Lenz F. Psychophysics of Sensations Evoked by Stimulation of the Human Central Nervous System. In The Senses: A Comprehensive Reference. Vol. 5. Elsevier Inc. 2010. p. 655-668 https://doi.org/10.1016/B978-012370880-9.00186-9
Ohara, S. ; Bagley, C. A. ; Lawson, H. C. ; Lenz, Frederick. / Psychophysics of Sensations Evoked by Stimulation of the Human Central Nervous System. The Senses: A Comprehensive Reference. Vol. 5 Elsevier Inc., 2010. pp. 655-668
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