Abstract
An increasing number of antipsychotic medications have demonstrated efficacy in randomized placebo-controlled trials in the treatment of children and adolescents with schizophrenia. This review summarizes and synthesizes relevant antipsychotic medication studies, with particular emphasis on second-generation agents, and discusses other clinical considerations that may influence medication selection. With the exception of clozapine demonstrating superior efficacy in the improvement of psychotic symptoms in treatment-resistant patients, many antipsychotic agents have been shown to be similarly efficacious, including first-generation medications. Consideration of the side-effect profile, which can differ substantially from medication to medication, is essential when choosing treatment options.
| Original language | English (US) |
|---|---|
| Journal | Child and Adolescent Psychiatric Clinics of North America |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Adolescents
- Antipsychotic medication
- Antipsychotic side effects
- Children
- Psychopharmacology
- Psychosis
- Schizophrenia
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Psychiatry and Mental health
Cite this
Psychopharmacologic Treatment of Schizophrenia in Adolescents and Children. / Lee, Esther S.; Kronsberg, Hal; Findling, Robert L.
In: Child and Adolescent Psychiatric Clinics of North America, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Psychopharmacologic Treatment of Schizophrenia in Adolescents and Children
AU - Lee, Esther S.
AU - Kronsberg, Hal
AU - Findling, Robert L.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - An increasing number of antipsychotic medications have demonstrated efficacy in randomized placebo-controlled trials in the treatment of children and adolescents with schizophrenia. This review summarizes and synthesizes relevant antipsychotic medication studies, with particular emphasis on second-generation agents, and discusses other clinical considerations that may influence medication selection. With the exception of clozapine demonstrating superior efficacy in the improvement of psychotic symptoms in treatment-resistant patients, many antipsychotic agents have been shown to be similarly efficacious, including first-generation medications. Consideration of the side-effect profile, which can differ substantially from medication to medication, is essential when choosing treatment options.
AB - An increasing number of antipsychotic medications have demonstrated efficacy in randomized placebo-controlled trials in the treatment of children and adolescents with schizophrenia. This review summarizes and synthesizes relevant antipsychotic medication studies, with particular emphasis on second-generation agents, and discusses other clinical considerations that may influence medication selection. With the exception of clozapine demonstrating superior efficacy in the improvement of psychotic symptoms in treatment-resistant patients, many antipsychotic agents have been shown to be similarly efficacious, including first-generation medications. Consideration of the side-effect profile, which can differ substantially from medication to medication, is essential when choosing treatment options.
KW - Adolescents
KW - Antipsychotic medication
KW - Antipsychotic side effects
KW - Children
KW - Psychopharmacology
KW - Psychosis
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85073154847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073154847&partnerID=8YFLogxK
U2 - 10.1016/j.chc.2019.08.009
DO - 10.1016/j.chc.2019.08.009
M3 - Review article
C2 - 31708047
AN - SCOPUS:85073154847
JO - Child and Adolescent Psychiatric Clinics of North America
JF - Child and Adolescent Psychiatric Clinics of North America
SN - 1056-4993
ER -