Psychopathology in first-episode schizophrenia and antibodies to Toxoplasma gondii

S. Bachmann, J. Schröder, C. Bottmer, E. F. Torrey, R. H. Yolken

Research output: Contribution to journalArticle

Abstract

Objective: Environmental factors such as infectious agents may contribute to the psychopathology and aetiology of schizophrenia. Toxoplasma gondii (TG) is a candidate infectious agent as it is known to replicate within the human central nervous system and to alter behaviour in experimental animals. Method: The relationship between antibodies to TG and psychopathological symptoms was examined in 34 first-episode patients with schizophrenia. Results: Results of regression analyses revealed that symptoms on admission, predictors of outcome, age and family history of psychiatric disease influenced the levels of antibodies to TG. Conclusions: These results indicate that TG infections may play a role in the clinical manifestation of psychopathology in a subgroup of patients with schizophrenia.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalPsychopathology
Volume38
Issue number2
DOIs
StatePublished - Mar 1 2005

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Keywords

  • Psychopathology
  • Schizophrenia, first episode
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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