Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment

Stephanie M. Sansone, Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, David Hessl

    Research output: Contribution to journalArticle

    Abstract

    Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist- Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

    Original languageEnglish (US)
    Pages (from-to)1377-1392
    Number of pages16
    JournalJournal of Autism and Developmental Disorders
    Volume42
    Issue number7
    DOIs
    StatePublished - Jul 2012

    Fingerprint

    Fragile X Syndrome
    Checklist
    Psychometrics
    Outcome Assessment (Health Care)
    Lethargy
    Neurobiology
    Intellectual Disability
    Statistical Factor Analysis
    Clinical Trials
    Sensitivity and Specificity

    Keywords

    • Autism
    • Factor analysis
    • FMR1 gene
    • Fragile X syndrome
    • Rating scale
    • Social avoidance

    ASJC Scopus subject areas

    • Developmental and Educational Psychology

    Cite this

    Sansone, S. M., Widaman, K. F., Hall, S. S., Reiss, A. L., Lightbody, A., Kaufmann, W. E., ... Hessl, D. (2012). Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment. Journal of Autism and Developmental Disorders, 42(7), 1377-1392. https://doi.org/10.1007/s10803-011-1370-2

    Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment. / Sansone, Stephanie M.; Widaman, Keith F.; Hall, Scott S.; Reiss, Allan L.; Lightbody, Amy; Kaufmann, Walter E.; Berry-Kravis, Elizabeth; Lachiewicz, Ave; Brown, Elaine C.; Hessl, David.

    In: Journal of Autism and Developmental Disorders, Vol. 42, No. 7, 07.2012, p. 1377-1392.

    Research output: Contribution to journalArticle

    Sansone, SM, Widaman, KF, Hall, SS, Reiss, AL, Lightbody, A, Kaufmann, WE, Berry-Kravis, E, Lachiewicz, A, Brown, EC & Hessl, D 2012, 'Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment', Journal of Autism and Developmental Disorders, vol. 42, no. 7, pp. 1377-1392. https://doi.org/10.1007/s10803-011-1370-2
    Sansone, Stephanie M. ; Widaman, Keith F. ; Hall, Scott S. ; Reiss, Allan L. ; Lightbody, Amy ; Kaufmann, Walter E. ; Berry-Kravis, Elizabeth ; Lachiewicz, Ave ; Brown, Elaine C. ; Hessl, David. / Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment. In: Journal of Autism and Developmental Disorders. 2012 ; Vol. 42, No. 7. pp. 1377-1392.
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