Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment

Stephanie M. Sansone; Keith F. Widaman; Scott S. Hall; Allan L. Reiss; Amy Lightbody; Walter E. Kaufmann; Elizabeth Berry-Kravis; Ave Lachiewicz; Elaine C. Brown; David Hessl

doi:10.1007/s10803-011-1370-2

Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment

Stephanie M. Sansone, Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, David Hessl

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist- Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

Original language	English (US)
Pages (from-to)	1377-1392
Number of pages	16
Journal	Journal of Autism and Developmental Disorders
Volume	42
Issue number	7
DOIs	https://doi.org/10.1007/s10803-011-1370-2
State	Published - Jul 2012
Externally published	Yes

Keywords

Autism
FMR1 gene
Factor analysis
Fragile X syndrome
Rating scale
Social avoidance

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1007/s10803-011-1370-2

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Sansone, S. M., Widaman, K. F., Hall, S. S., Reiss, A. L., Lightbody, A., Kaufmann, W. E., Berry-Kravis, E., Lachiewicz, A., Brown, E. C., & Hessl, D. (2012). Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment. Journal of Autism and Developmental Disorders, 42(7), 1377-1392. https://doi.org/10.1007/s10803-011-1370-2

Sansone, SM, Widaman, KF, Hall, SS, Reiss, AL, Lightbody, A, Kaufmann, WE, Berry-Kravis, E, Lachiewicz, A, Brown, EC & Hessl, D 2012, 'Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment', Journal of Autism and Developmental Disorders, vol. 42, no. 7, pp. 1377-1392. https://doi.org/10.1007/s10803-011-1370-2

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abstract = "Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist- Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.",

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author = "Sansone, {Stephanie M.} and Widaman, {Keith F.} and Hall, {Scott S.} and Reiss, {Allan L.} and Amy Lightbody and Kaufmann, {Walter E.} and Elizabeth Berry-Kravis and Ave Lachiewicz and Brown, {Elaine C.} and David Hessl",

note = "Funding Information: Acknowledgments We are especially grateful for the participants and their families for their contribution to the understanding of fragile X syndrome. We would also like to thank Lisa Cordeiro, Elizabeth Ballinger, Alyssa Chavez, Ava Rezvani, Lia Boyle, Victor Talisa, Nana Asante, Crystal Hervey, and Anna DeSonia for their help with site coordination, data entry and management. This work was supported by NIH K23MH77554 (Hessl), the National Fragile X Foundation (Hessl), FRAXA (Hessl), NIH K08MH081998 (Hall), R01MH050047 (Reiss), and NIH HD24061 (Kaufmann).",

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Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment

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Keywords

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