Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment

Stephanie M. Sansone, Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, David Hessl

    Research output: Contribution to journalArticle

    Abstract

    Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist- Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

    Original languageEnglish (US)
    Pages (from-to)1377-1392
    Number of pages16
    JournalJournal of Autism and Developmental Disorders
    Volume42
    Issue number7
    DOIs
    StatePublished - Jul 1 2012

    Keywords

    • Autism
    • FMR1 gene
    • Factor analysis
    • Fragile X syndrome
    • Rating scale
    • Social avoidance

    ASJC Scopus subject areas

    • Developmental and Educational Psychology

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