Psychometric evaluation and adaptation of the Spine Oncology Study Group Outcomes Questionnaire to evaluate health-related quality of life in patients with spinal metastases

Anne L. Versteeg, Arjun Sahgal, Laurence D. Rhines, Daniel Sciubba, James M. Schuster, Michael H. Weber, Peter Pal Varga, Stefano Boriani, Chetan Bettegowda, Michael G. Fehlings, Michelle J. Clarke, Paul M. Arnold, Ziya L. Gokaslan, Charles G. Fisher

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ) was developed as the first spine oncology-specific health-related quality of life (HRQOL) measure. This study evaluated the psychometric properties and clinical validity of the SOSGOQ in a diverse cohort of patients with spinal metastases. METHODS: An international, multicenter, prospective observational cohort study including patients with spinal metastases who underwent surgery and/or radiotherapy was conducted by the AOSpine Knowledge Forum Tumor. Demographic, tumor, and treatment data were collected. HRQOL was evaluated using the SOSGOQ and Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36) at baseline and fixed follow-up times. Construct validity was assessed using multitrait scaling analyses, confirmatory factor analyses, and correlation with the SF-36 and NRS pain score. Test-retest reliability was assessed in a subgroup of patients between 12 weeks after treatment and the retest 4 to 9 days later. RESULTS: A total of 238 patients were enrolled at 9 centers across North America; 153 of these patients had HRQOL data available at 12 weeks after treatment. Multitrait scaling analyses and confirmatory factor analyses resulted in a refined version of the SOSGOQ with 4 domains and 4 single items. The revised SOSGOQ (SOSGOQ2.0) demonstrated strong correlations with SF-36 and the ability to discriminate between clinically distinct patient groups. Reliability of the SOSGOQ2.0 was demonstrated to be good, with an intraclass correlation coefficient ranging from 0.58 to 0.92 for the different domains. CONCLUSIONS: The SOSGOQ2.0 is a reliable and valid measure with which to evaluate HRQOL in patients with spinal metastases. It is recommended to use the SOSGOQ2.0 together with a generic HRQOL outcome measure to comprehensively assess HRQOL and increase sensitivity and specificity.

Original languageEnglish (US)
JournalCancer
DOIs
StateAccepted/In press - Jan 1 2018

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Psychometrics
Spine
Quality of Life
Outcome Assessment (Health Care)
Neoplasm Metastasis
Statistical Factor Analysis
Aptitude
North America
Surveys and Questionnaires
Health Surveys
Reproducibility of Results
Observational Studies
Neoplasms
Cohort Studies
Radiotherapy
Therapeutics
Demography
Sensitivity and Specificity
Pain

Keywords

  • Metastases
  • Patient-reported outcomes
  • Quality of life
  • Reliability
  • Spine
  • Validity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Psychometric evaluation and adaptation of the Spine Oncology Study Group Outcomes Questionnaire to evaluate health-related quality of life in patients with spinal metastases. / Versteeg, Anne L.; Sahgal, Arjun; Rhines, Laurence D.; Sciubba, Daniel; Schuster, James M.; Weber, Michael H.; Varga, Peter Pal; Boriani, Stefano; Bettegowda, Chetan; Fehlings, Michael G.; Clarke, Michelle J.; Arnold, Paul M.; Gokaslan, Ziya L.; Fisher, Charles G.

In: Cancer, 01.01.2018.

Research output: Contribution to journalArticle

Versteeg, AL, Sahgal, A, Rhines, LD, Sciubba, D, Schuster, JM, Weber, MH, Varga, PP, Boriani, S, Bettegowda, C, Fehlings, MG, Clarke, MJ, Arnold, PM, Gokaslan, ZL & Fisher, CG 2018, 'Psychometric evaluation and adaptation of the Spine Oncology Study Group Outcomes Questionnaire to evaluate health-related quality of life in patients with spinal metastases', Cancer. https://doi.org/10.1002/cncr.31240
Versteeg, Anne L. ; Sahgal, Arjun ; Rhines, Laurence D. ; Sciubba, Daniel ; Schuster, James M. ; Weber, Michael H. ; Varga, Peter Pal ; Boriani, Stefano ; Bettegowda, Chetan ; Fehlings, Michael G. ; Clarke, Michelle J. ; Arnold, Paul M. ; Gokaslan, Ziya L. ; Fisher, Charles G. / Psychometric evaluation and adaptation of the Spine Oncology Study Group Outcomes Questionnaire to evaluate health-related quality of life in patients with spinal metastases. In: Cancer. 2018.
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abstract = "BACKGROUND: The Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ) was developed as the first spine oncology-specific health-related quality of life (HRQOL) measure. This study evaluated the psychometric properties and clinical validity of the SOSGOQ in a diverse cohort of patients with spinal metastases. METHODS: An international, multicenter, prospective observational cohort study including patients with spinal metastases who underwent surgery and/or radiotherapy was conducted by the AOSpine Knowledge Forum Tumor. Demographic, tumor, and treatment data were collected. HRQOL was evaluated using the SOSGOQ and Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36) at baseline and fixed follow-up times. Construct validity was assessed using multitrait scaling analyses, confirmatory factor analyses, and correlation with the SF-36 and NRS pain score. Test-retest reliability was assessed in a subgroup of patients between 12 weeks after treatment and the retest 4 to 9 days later. RESULTS: A total of 238 patients were enrolled at 9 centers across North America; 153 of these patients had HRQOL data available at 12 weeks after treatment. Multitrait scaling analyses and confirmatory factor analyses resulted in a refined version of the SOSGOQ with 4 domains and 4 single items. The revised SOSGOQ (SOSGOQ2.0) demonstrated strong correlations with SF-36 and the ability to discriminate between clinically distinct patient groups. Reliability of the SOSGOQ2.0 was demonstrated to be good, with an intraclass correlation coefficient ranging from 0.58 to 0.92 for the different domains. CONCLUSIONS: The SOSGOQ2.0 is a reliable and valid measure with which to evaluate HRQOL in patients with spinal metastases. It is recommended to use the SOSGOQ2.0 together with a generic HRQOL outcome measure to comprehensively assess HRQOL and increase sensitivity and specificity.",
keywords = "Metastases, Patient-reported outcomes, Quality of life, Reliability, Spine, Validity",
author = "Versteeg, {Anne L.} and Arjun Sahgal and Rhines, {Laurence D.} and Daniel Sciubba and Schuster, {James M.} and Weber, {Michael H.} and Varga, {Peter Pal} and Stefano Boriani and Chetan Bettegowda and Fehlings, {Michael G.} and Clarke, {Michelle J.} and Arnold, {Paul M.} and Gokaslan, {Ziya L.} and Fisher, {Charles G.}",
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T1 - Psychometric evaluation and adaptation of the Spine Oncology Study Group Outcomes Questionnaire to evaluate health-related quality of life in patients with spinal metastases

AU - Versteeg, Anne L.

AU - Sahgal, Arjun

AU - Rhines, Laurence D.

AU - Sciubba, Daniel

AU - Schuster, James M.

AU - Weber, Michael H.

AU - Varga, Peter Pal

AU - Boriani, Stefano

AU - Bettegowda, Chetan

AU - Fehlings, Michael G.

AU - Clarke, Michelle J.

AU - Arnold, Paul M.

AU - Gokaslan, Ziya L.

AU - Fisher, Charles G.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: The Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ) was developed as the first spine oncology-specific health-related quality of life (HRQOL) measure. This study evaluated the psychometric properties and clinical validity of the SOSGOQ in a diverse cohort of patients with spinal metastases. METHODS: An international, multicenter, prospective observational cohort study including patients with spinal metastases who underwent surgery and/or radiotherapy was conducted by the AOSpine Knowledge Forum Tumor. Demographic, tumor, and treatment data were collected. HRQOL was evaluated using the SOSGOQ and Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36) at baseline and fixed follow-up times. Construct validity was assessed using multitrait scaling analyses, confirmatory factor analyses, and correlation with the SF-36 and NRS pain score. Test-retest reliability was assessed in a subgroup of patients between 12 weeks after treatment and the retest 4 to 9 days later. RESULTS: A total of 238 patients were enrolled at 9 centers across North America; 153 of these patients had HRQOL data available at 12 weeks after treatment. Multitrait scaling analyses and confirmatory factor analyses resulted in a refined version of the SOSGOQ with 4 domains and 4 single items. The revised SOSGOQ (SOSGOQ2.0) demonstrated strong correlations with SF-36 and the ability to discriminate between clinically distinct patient groups. Reliability of the SOSGOQ2.0 was demonstrated to be good, with an intraclass correlation coefficient ranging from 0.58 to 0.92 for the different domains. CONCLUSIONS: The SOSGOQ2.0 is a reliable and valid measure with which to evaluate HRQOL in patients with spinal metastases. It is recommended to use the SOSGOQ2.0 together with a generic HRQOL outcome measure to comprehensively assess HRQOL and increase sensitivity and specificity.

AB - BACKGROUND: The Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ) was developed as the first spine oncology-specific health-related quality of life (HRQOL) measure. This study evaluated the psychometric properties and clinical validity of the SOSGOQ in a diverse cohort of patients with spinal metastases. METHODS: An international, multicenter, prospective observational cohort study including patients with spinal metastases who underwent surgery and/or radiotherapy was conducted by the AOSpine Knowledge Forum Tumor. Demographic, tumor, and treatment data were collected. HRQOL was evaluated using the SOSGOQ and Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36) at baseline and fixed follow-up times. Construct validity was assessed using multitrait scaling analyses, confirmatory factor analyses, and correlation with the SF-36 and NRS pain score. Test-retest reliability was assessed in a subgroup of patients between 12 weeks after treatment and the retest 4 to 9 days later. RESULTS: A total of 238 patients were enrolled at 9 centers across North America; 153 of these patients had HRQOL data available at 12 weeks after treatment. Multitrait scaling analyses and confirmatory factor analyses resulted in a refined version of the SOSGOQ with 4 domains and 4 single items. The revised SOSGOQ (SOSGOQ2.0) demonstrated strong correlations with SF-36 and the ability to discriminate between clinically distinct patient groups. Reliability of the SOSGOQ2.0 was demonstrated to be good, with an intraclass correlation coefficient ranging from 0.58 to 0.92 for the different domains. CONCLUSIONS: The SOSGOQ2.0 is a reliable and valid measure with which to evaluate HRQOL in patients with spinal metastases. It is recommended to use the SOSGOQ2.0 together with a generic HRQOL outcome measure to comprehensively assess HRQOL and increase sensitivity and specificity.

KW - Metastases

KW - Patient-reported outcomes

KW - Quality of life

KW - Reliability

KW - Spine

KW - Validity

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