Psychological health impact on 2-year changes in pain and function in persons with knee pain: Data from the osteoarthritis initiative

D. L. Riddle, X. Kong, G. K. Fitzgerald

Research output: Contribution to journalArticle

Abstract

Objective: We determined whether baseline depressive symptoms, knee-related confidence and general psychological distress influenced changes in pain and function during 2 years of follow-up. Design: We included persons in the Osteoarthritis Initiative (OAI) dataset with baseline pain of 1 or greater on a 0-10 scale in at least one knee and no knee or hip surgery during the 2-year follow-up (n = 3407). The four outcome variables were repeated chair standing, 20. m walk and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Disability. Linear mixed effects models assessed the association of each mental health variable with the yearly change in each baseline adjusted outcome measure after controlling for covariates. Results: Depressive symptoms were significantly predictive of worsening in most outcomes. The magnitude of worsening predicted for each year was small. For example, the dichotomized WOMAC Pain model indicated that depressed persons experience more rapid worsening than non-depressed persons at an average rate of 0.59 WOMAC points per year (95% CI 0.176, 1.013, P= 0.005). Similar significant but very small effects of depressive symptoms on other outcomes were observed. Knee confidence was not predictive of change. General psychological distress was predictive of change in 20-m walk and WOMAC Pain. Conclusions: The most consistent psychological predictor of yearly worsening was baseline depressive symptoms. Although a statistically robust predictor of outcome, given that change was very small and highly dependent on baseline status, our results indicate that a considerable degree of persistent depressive symptoms would be required to have a meaningful effect on future self-reported outcome.

Original languageEnglish (US)
Pages (from-to)1095-1101
Number of pages7
JournalOsteoarthritis and Cartilage
Volume19
Issue number9
DOIs
StatePublished - Sep 2011

Fingerprint

Osteoarthritis
Knee
Health
Depression
Psychology
Pain
Surgery
Mental Health Associations
Ontario
Hip
Outcome Assessment (Health Care)

Keywords

  • Arthroplasty
  • Depression
  • Knee

ASJC Scopus subject areas

  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Psychological health impact on 2-year changes in pain and function in persons with knee pain : Data from the osteoarthritis initiative. / Riddle, D. L.; Kong, X.; Fitzgerald, G. K.

In: Osteoarthritis and Cartilage, Vol. 19, No. 9, 09.2011, p. 1095-1101.

Research output: Contribution to journalArticle

@article{9dcadd3403dc4eeea0bfb7e1cfa96168,
title = "Psychological health impact on 2-year changes in pain and function in persons with knee pain: Data from the osteoarthritis initiative",
abstract = "Objective: We determined whether baseline depressive symptoms, knee-related confidence and general psychological distress influenced changes in pain and function during 2 years of follow-up. Design: We included persons in the Osteoarthritis Initiative (OAI) dataset with baseline pain of 1 or greater on a 0-10 scale in at least one knee and no knee or hip surgery during the 2-year follow-up (n = 3407). The four outcome variables were repeated chair standing, 20. m walk and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Disability. Linear mixed effects models assessed the association of each mental health variable with the yearly change in each baseline adjusted outcome measure after controlling for covariates. Results: Depressive symptoms were significantly predictive of worsening in most outcomes. The magnitude of worsening predicted for each year was small. For example, the dichotomized WOMAC Pain model indicated that depressed persons experience more rapid worsening than non-depressed persons at an average rate of 0.59 WOMAC points per year (95{\%} CI 0.176, 1.013, P= 0.005). Similar significant but very small effects of depressive symptoms on other outcomes were observed. Knee confidence was not predictive of change. General psychological distress was predictive of change in 20-m walk and WOMAC Pain. Conclusions: The most consistent psychological predictor of yearly worsening was baseline depressive symptoms. Although a statistically robust predictor of outcome, given that change was very small and highly dependent on baseline status, our results indicate that a considerable degree of persistent depressive symptoms would be required to have a meaningful effect on future self-reported outcome.",
keywords = "Arthroplasty, Depression, Knee",
author = "Riddle, {D. L.} and X. Kong and Fitzgerald, {G. K.}",
year = "2011",
month = "9",
doi = "10.1016/j.joca.2011.06.003",
language = "English (US)",
volume = "19",
pages = "1095--1101",
journal = "Osteoarthritis and Cartilage",
issn = "1063-4584",
publisher = "W.B. Saunders Ltd",
number = "9",

}

TY - JOUR

T1 - Psychological health impact on 2-year changes in pain and function in persons with knee pain

T2 - Data from the osteoarthritis initiative

AU - Riddle, D. L.

AU - Kong, X.

AU - Fitzgerald, G. K.

PY - 2011/9

Y1 - 2011/9

N2 - Objective: We determined whether baseline depressive symptoms, knee-related confidence and general psychological distress influenced changes in pain and function during 2 years of follow-up. Design: We included persons in the Osteoarthritis Initiative (OAI) dataset with baseline pain of 1 or greater on a 0-10 scale in at least one knee and no knee or hip surgery during the 2-year follow-up (n = 3407). The four outcome variables were repeated chair standing, 20. m walk and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Disability. Linear mixed effects models assessed the association of each mental health variable with the yearly change in each baseline adjusted outcome measure after controlling for covariates. Results: Depressive symptoms were significantly predictive of worsening in most outcomes. The magnitude of worsening predicted for each year was small. For example, the dichotomized WOMAC Pain model indicated that depressed persons experience more rapid worsening than non-depressed persons at an average rate of 0.59 WOMAC points per year (95% CI 0.176, 1.013, P= 0.005). Similar significant but very small effects of depressive symptoms on other outcomes were observed. Knee confidence was not predictive of change. General psychological distress was predictive of change in 20-m walk and WOMAC Pain. Conclusions: The most consistent psychological predictor of yearly worsening was baseline depressive symptoms. Although a statistically robust predictor of outcome, given that change was very small and highly dependent on baseline status, our results indicate that a considerable degree of persistent depressive symptoms would be required to have a meaningful effect on future self-reported outcome.

AB - Objective: We determined whether baseline depressive symptoms, knee-related confidence and general psychological distress influenced changes in pain and function during 2 years of follow-up. Design: We included persons in the Osteoarthritis Initiative (OAI) dataset with baseline pain of 1 or greater on a 0-10 scale in at least one knee and no knee or hip surgery during the 2-year follow-up (n = 3407). The four outcome variables were repeated chair standing, 20. m walk and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Disability. Linear mixed effects models assessed the association of each mental health variable with the yearly change in each baseline adjusted outcome measure after controlling for covariates. Results: Depressive symptoms were significantly predictive of worsening in most outcomes. The magnitude of worsening predicted for each year was small. For example, the dichotomized WOMAC Pain model indicated that depressed persons experience more rapid worsening than non-depressed persons at an average rate of 0.59 WOMAC points per year (95% CI 0.176, 1.013, P= 0.005). Similar significant but very small effects of depressive symptoms on other outcomes were observed. Knee confidence was not predictive of change. General psychological distress was predictive of change in 20-m walk and WOMAC Pain. Conclusions: The most consistent psychological predictor of yearly worsening was baseline depressive symptoms. Although a statistically robust predictor of outcome, given that change was very small and highly dependent on baseline status, our results indicate that a considerable degree of persistent depressive symptoms would be required to have a meaningful effect on future self-reported outcome.

KW - Arthroplasty

KW - Depression

KW - Knee

UR - http://www.scopus.com/inward/record.url?scp=80051797562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051797562&partnerID=8YFLogxK

U2 - 10.1016/j.joca.2011.06.003

DO - 10.1016/j.joca.2011.06.003

M3 - Article

C2 - 21723400

AN - SCOPUS:80051797562

VL - 19

SP - 1095

EP - 1101

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 9

ER -