Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis

William L. Hasler, Henry P. Parkman, Laura Wilson, Pankaj Jay Pasricha, Kenneth L. Koch, Thomas L. Abell, William J. Snape, Gianrico Farrugia, Linda A Lee, James A Tonascia, Aynur Unalp-Arida, Frank Hamilton

Research output: Contribution to journalArticle

Abstract

Objectives: Gastroparesis patients may have associated psychological distress. This study aimed to measure depression and anxiety in gastroparesis in relation to disease severity, etiology, and gastric retention. Methods: Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) scores for state (Y1) and trait (Y2) anxiety were obtained from 299 gastroparesis patients from 6 centers of the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Severity was investigator graded as grades 1, 2, or 3 and patient reported by Gastroparesis Cardinal Symptom Index (GCSI) scores. Antiemetic/prokinetic medication use, anxiolytic and antidepressant medication use, supplemental feedings, and hospitalizations were recorded. BDI, Y1, and Y2 scores were compared in diabetic vs. idiopathic etiologies and mild (≤20%) vs. moderate (>20-35%) vs. severe (>35-50%) vs. very severe (>50%) gastric retention at 4 h. Results: BDI, Y1, and Y2 scores were greater with increasing degrees of investigator-rated gastroparesis severity (P0.05). BDI, Y1, and Y2 scores were higher for GCSI >3.1 vs. π3.1 (P0.05). Anxiolytic use was more common with Y1≥46; antidepressant use and 6 hospitalizations/year were more common with Y244 (P=0.05). BDI, Y1, and Y2 scores were not different in diabetic and idiopathic gastroparesis and did not relate to degree of gastric retention. On logistic regression, GCSI 3.1 was associated with BDI 20 and Y146; antiemetic/prokinetic use was associated with BDI20; anxiolytic use was associated with Y146; and antidepressant use was associated with Y244. Conclusions: Higher depression and anxiety scores are associated with gastroparesis severity on investigator- and patient-reported assessments. Psychological dysfunction does not vary by etiology or degree of gastric retention. Psychological features should be considered in managing gastroparesis.

Original languageEnglish (US)
Pages (from-to)2357-2367
Number of pages11
JournalAmerican Journal of Gastroenterology
Volume105
Issue number11
DOIs
StatePublished - Nov 2010

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Gastroparesis
Stomach
Psychology
Depression
Equipment and Supplies
Anti-Anxiety Agents
Anxiety
Antidepressive Agents
Antiemetics
Research Personnel
Hospitalization
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Logistic Models

ASJC Scopus subject areas

  • Gastroenterology

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Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis. / Hasler, William L.; Parkman, Henry P.; Wilson, Laura; Pasricha, Pankaj Jay; Koch, Kenneth L.; Abell, Thomas L.; Snape, William J.; Farrugia, Gianrico; Lee, Linda A; Tonascia, James A; Unalp-Arida, Aynur; Hamilton, Frank.

In: American Journal of Gastroenterology, Vol. 105, No. 11, 11.2010, p. 2357-2367.

Research output: Contribution to journalArticle

Hasler, William L. ; Parkman, Henry P. ; Wilson, Laura ; Pasricha, Pankaj Jay ; Koch, Kenneth L. ; Abell, Thomas L. ; Snape, William J. ; Farrugia, Gianrico ; Lee, Linda A ; Tonascia, James A ; Unalp-Arida, Aynur ; Hamilton, Frank. / Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis. In: American Journal of Gastroenterology. 2010 ; Vol. 105, No. 11. pp. 2357-2367.
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abstract = "Objectives: Gastroparesis patients may have associated psychological distress. This study aimed to measure depression and anxiety in gastroparesis in relation to disease severity, etiology, and gastric retention. Methods: Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) scores for state (Y1) and trait (Y2) anxiety were obtained from 299 gastroparesis patients from 6 centers of the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Severity was investigator graded as grades 1, 2, or 3 and patient reported by Gastroparesis Cardinal Symptom Index (GCSI) scores. Antiemetic/prokinetic medication use, anxiolytic and antidepressant medication use, supplemental feedings, and hospitalizations were recorded. BDI, Y1, and Y2 scores were compared in diabetic vs. idiopathic etiologies and mild (≤20{\%}) vs. moderate (>20-35{\%}) vs. severe (>35-50{\%}) vs. very severe (>50{\%}) gastric retention at 4 h. Results: BDI, Y1, and Y2 scores were greater with increasing degrees of investigator-rated gastroparesis severity (P0.05). BDI, Y1, and Y2 scores were higher for GCSI >3.1 vs. π3.1 (P0.05). Anxiolytic use was more common with Y1≥46; antidepressant use and 6 hospitalizations/year were more common with Y244 (P=0.05). BDI, Y1, and Y2 scores were not different in diabetic and idiopathic gastroparesis and did not relate to degree of gastric retention. On logistic regression, GCSI 3.1 was associated with BDI 20 and Y146; antiemetic/prokinetic use was associated with BDI20; anxiolytic use was associated with Y146; and antidepressant use was associated with Y244. Conclusions: Higher depression and anxiety scores are associated with gastroparesis severity on investigator- and patient-reported assessments. Psychological dysfunction does not vary by etiology or degree of gastric retention. Psychological features should be considered in managing gastroparesis.",
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T1 - Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis

AU - Hasler, William L.

AU - Parkman, Henry P.

AU - Wilson, Laura

AU - Pasricha, Pankaj Jay

AU - Koch, Kenneth L.

AU - Abell, Thomas L.

AU - Snape, William J.

AU - Farrugia, Gianrico

AU - Lee, Linda A

AU - Tonascia, James A

AU - Unalp-Arida, Aynur

AU - Hamilton, Frank

PY - 2010/11

Y1 - 2010/11

N2 - Objectives: Gastroparesis patients may have associated psychological distress. This study aimed to measure depression and anxiety in gastroparesis in relation to disease severity, etiology, and gastric retention. Methods: Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) scores for state (Y1) and trait (Y2) anxiety were obtained from 299 gastroparesis patients from 6 centers of the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Severity was investigator graded as grades 1, 2, or 3 and patient reported by Gastroparesis Cardinal Symptom Index (GCSI) scores. Antiemetic/prokinetic medication use, anxiolytic and antidepressant medication use, supplemental feedings, and hospitalizations were recorded. BDI, Y1, and Y2 scores were compared in diabetic vs. idiopathic etiologies and mild (≤20%) vs. moderate (>20-35%) vs. severe (>35-50%) vs. very severe (>50%) gastric retention at 4 h. Results: BDI, Y1, and Y2 scores were greater with increasing degrees of investigator-rated gastroparesis severity (P0.05). BDI, Y1, and Y2 scores were higher for GCSI >3.1 vs. π3.1 (P0.05). Anxiolytic use was more common with Y1≥46; antidepressant use and 6 hospitalizations/year were more common with Y244 (P=0.05). BDI, Y1, and Y2 scores were not different in diabetic and idiopathic gastroparesis and did not relate to degree of gastric retention. On logistic regression, GCSI 3.1 was associated with BDI 20 and Y146; antiemetic/prokinetic use was associated with BDI20; anxiolytic use was associated with Y146; and antidepressant use was associated with Y244. Conclusions: Higher depression and anxiety scores are associated with gastroparesis severity on investigator- and patient-reported assessments. Psychological dysfunction does not vary by etiology or degree of gastric retention. Psychological features should be considered in managing gastroparesis.

AB - Objectives: Gastroparesis patients may have associated psychological distress. This study aimed to measure depression and anxiety in gastroparesis in relation to disease severity, etiology, and gastric retention. Methods: Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) scores for state (Y1) and trait (Y2) anxiety were obtained from 299 gastroparesis patients from 6 centers of the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Severity was investigator graded as grades 1, 2, or 3 and patient reported by Gastroparesis Cardinal Symptom Index (GCSI) scores. Antiemetic/prokinetic medication use, anxiolytic and antidepressant medication use, supplemental feedings, and hospitalizations were recorded. BDI, Y1, and Y2 scores were compared in diabetic vs. idiopathic etiologies and mild (≤20%) vs. moderate (>20-35%) vs. severe (>35-50%) vs. very severe (>50%) gastric retention at 4 h. Results: BDI, Y1, and Y2 scores were greater with increasing degrees of investigator-rated gastroparesis severity (P0.05). BDI, Y1, and Y2 scores were higher for GCSI >3.1 vs. π3.1 (P0.05). Anxiolytic use was more common with Y1≥46; antidepressant use and 6 hospitalizations/year were more common with Y244 (P=0.05). BDI, Y1, and Y2 scores were not different in diabetic and idiopathic gastroparesis and did not relate to degree of gastric retention. On logistic regression, GCSI 3.1 was associated with BDI 20 and Y146; antiemetic/prokinetic use was associated with BDI20; anxiolytic use was associated with Y146; and antidepressant use was associated with Y244. Conclusions: Higher depression and anxiety scores are associated with gastroparesis severity on investigator- and patient-reported assessments. Psychological dysfunction does not vary by etiology or degree of gastric retention. Psychological features should be considered in managing gastroparesis.

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