Psychological distress and physical pain appear to have no short-term adverse impact on plasma HIV-1 RNA levels in patients on successful HAART

Richard E. Nettles, Tara L. Kieffer, Joseph Cofrancesco, Joel E. Gallant, Thomas C Quinn, Brooks Jackson, Charles Williams Flexner, Kathryn Anne Carson, Albert W Wu, Robert F Siliciano

Research output: Contribution to journalArticle

Abstract

Purpose: Previous studies have linked depression and stressful life events in HIV disease with a more rapid decline in CD4 count and progression to AIDS. However, the short-term effect of psychological and physical distress on HIV-1 RNA levels in patients on successful HAART has not been well studied. Method: Ten asymptomatic HIV-infected adults with suppression of viremia to 50 copies/mL. Psychological distress and physical pain were not associated with episodes of detectable viremia. Conclusion: Using frequent monitoring of HIV-1 RNA levels and patient ratings of mood, stress, and pain, we found that psychological distress and physical pain had no short-term adverse impact on HIV-1 RNA levels in highly adherent patients with stable suppression of viremia on HAART.

Original languageEnglish (US)
Pages (from-to)262-271
Number of pages10
JournalHIV Clinical Trials
Volume6
Issue number5
DOIs
Publication statusPublished - Sep 2005

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Keywords

  • HIV
  • Pain
  • Viral load

ASJC Scopus subject areas

  • Virology
  • Immunology

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