Psychoactivity of atropine in normal volunteers

David M. Penetar, Jack E. Henningfield

Research output: Contribution to journalArticle

Abstract

Subjective effects of atropine sulfate injections were assessed in normal volunteers (n=10), as one portion of a 3-part study (behavioral, subjective and physiologic effects of atropine). Each volunteer was given 0, 2 or 4 mg/70 kg atropine sulfate intramuscularly according to randomized block sequences on different test days. To assess psychoactivity of atropine, the Single Dose Questionnaire (SDQ) and the Addiction Research Center Inventory (ARCI) were given 1 hr before and 1 hr following drug injections. Data from the SDQ indicated that atropine produced significant discriminable effects but did not elevate scores on a drug liking scale. Data from the ARCI indicated that atropine produced significant sedative-like effects (pentobarbital-chlorpromazine-alcohol scale). Taken together, the data from the psychometric instruments confirms that atropine is a drug of relatively low abuse potential.

Original languageEnglish (US)
Pages (from-to)1111-1113
Number of pages3
JournalPharmacology Biochemistry and Behavior
Volume24
Issue number4
DOIs
StatePublished - 1986

Fingerprint

Atropine
Healthy Volunteers
Pharmaceutical Preparations
Equipment and Supplies
Injections
Chlorpromazine
Pentobarbital
Hypnotics and Sedatives
Research
Psychometrics
Volunteers
Alcohols

Keywords

  • Addiction Research Center Inventory
  • Atropine
  • Cholinergic antagonists
  • Drug abuse
  • Human research
  • Performance assessment battery
  • Psychometrics

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Psychoactivity of atropine in normal volunteers. / Penetar, David M.; Henningfield, Jack E.

In: Pharmacology Biochemistry and Behavior, Vol. 24, No. 4, 1986, p. 1111-1113.

Research output: Contribution to journalArticle

Penetar, David M. ; Henningfield, Jack E. / Psychoactivity of atropine in normal volunteers. In: Pharmacology Biochemistry and Behavior. 1986 ; Vol. 24, No. 4. pp. 1111-1113.
@article{6a2d4f25ea2046538dc636cb1800878e,
title = "Psychoactivity of atropine in normal volunteers",
abstract = "Subjective effects of atropine sulfate injections were assessed in normal volunteers (n=10), as one portion of a 3-part study (behavioral, subjective and physiologic effects of atropine). Each volunteer was given 0, 2 or 4 mg/70 kg atropine sulfate intramuscularly according to randomized block sequences on different test days. To assess psychoactivity of atropine, the Single Dose Questionnaire (SDQ) and the Addiction Research Center Inventory (ARCI) were given 1 hr before and 1 hr following drug injections. Data from the SDQ indicated that atropine produced significant discriminable effects but did not elevate scores on a drug liking scale. Data from the ARCI indicated that atropine produced significant sedative-like effects (pentobarbital-chlorpromazine-alcohol scale). Taken together, the data from the psychometric instruments confirms that atropine is a drug of relatively low abuse potential.",
keywords = "Addiction Research Center Inventory, Atropine, Cholinergic antagonists, Drug abuse, Human research, Performance assessment battery, Psychometrics",
author = "Penetar, {David M.} and Henningfield, {Jack E.}",
year = "1986",
doi = "10.1016/0091-3057(86)90463-6",
language = "English (US)",
volume = "24",
pages = "1111--1113",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Psychoactivity of atropine in normal volunteers

AU - Penetar, David M.

AU - Henningfield, Jack E.

PY - 1986

Y1 - 1986

N2 - Subjective effects of atropine sulfate injections were assessed in normal volunteers (n=10), as one portion of a 3-part study (behavioral, subjective and physiologic effects of atropine). Each volunteer was given 0, 2 or 4 mg/70 kg atropine sulfate intramuscularly according to randomized block sequences on different test days. To assess psychoactivity of atropine, the Single Dose Questionnaire (SDQ) and the Addiction Research Center Inventory (ARCI) were given 1 hr before and 1 hr following drug injections. Data from the SDQ indicated that atropine produced significant discriminable effects but did not elevate scores on a drug liking scale. Data from the ARCI indicated that atropine produced significant sedative-like effects (pentobarbital-chlorpromazine-alcohol scale). Taken together, the data from the psychometric instruments confirms that atropine is a drug of relatively low abuse potential.

AB - Subjective effects of atropine sulfate injections were assessed in normal volunteers (n=10), as one portion of a 3-part study (behavioral, subjective and physiologic effects of atropine). Each volunteer was given 0, 2 or 4 mg/70 kg atropine sulfate intramuscularly according to randomized block sequences on different test days. To assess psychoactivity of atropine, the Single Dose Questionnaire (SDQ) and the Addiction Research Center Inventory (ARCI) were given 1 hr before and 1 hr following drug injections. Data from the SDQ indicated that atropine produced significant discriminable effects but did not elevate scores on a drug liking scale. Data from the ARCI indicated that atropine produced significant sedative-like effects (pentobarbital-chlorpromazine-alcohol scale). Taken together, the data from the psychometric instruments confirms that atropine is a drug of relatively low abuse potential.

KW - Addiction Research Center Inventory

KW - Atropine

KW - Cholinergic antagonists

KW - Drug abuse

KW - Human research

KW - Performance assessment battery

KW - Psychometrics

UR - http://www.scopus.com/inward/record.url?scp=0022900081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022900081&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(86)90463-6

DO - 10.1016/0091-3057(86)90463-6

M3 - Article

C2 - 3714767

AN - SCOPUS:0022900081

VL - 24

SP - 1111

EP - 1113

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -