TY - JOUR
T1 - Psychiatric genetics
T2 - Progress amid controversy
AU - Burmeister, Margit
AU - McInnis, Melvin G.
AU - Zöllner, Sebastian
N1 - Funding Information:
We thank J. Li, M. Boehnke, S. Sen and M. Meisler for comments on the manuscript. Funding of our work in psychiatric disorders is provided by the Nancy Pritzker Psychiatric Disorders Fund, the Heinz Prechter Bipolar Disorders fund, NARSAD, and the National Institutes of Health (MH070775, MH070793).
PY - 2008/7
Y1 - 2008/7
N2 - Several psychiatric disorders - such as bipolar disorder, schizophrenia and autism - are highly heritable, yet identifying their genetic basis has been challenging, with most discoveries failing to be replicated. However, inroads have been made by the incorporation of intermediate traits (endophenotypes) and of environmental factors into genetic analyses, and through the identification of rare inherited variants and novel structural mutations. Current efforts aim to increase sample sizes by gathering larger samples for case-control studies or through meta-analyses of such studies. More attention on unique families, rare variants, and on incorporating environment and the emerging knowledge of biological function and pathways into genetic analysis is warranted.
AB - Several psychiatric disorders - such as bipolar disorder, schizophrenia and autism - are highly heritable, yet identifying their genetic basis has been challenging, with most discoveries failing to be replicated. However, inroads have been made by the incorporation of intermediate traits (endophenotypes) and of environmental factors into genetic analyses, and through the identification of rare inherited variants and novel structural mutations. Current efforts aim to increase sample sizes by gathering larger samples for case-control studies or through meta-analyses of such studies. More attention on unique families, rare variants, and on incorporating environment and the emerging knowledge of biological function and pathways into genetic analysis is warranted.
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U2 - 10.1038/nrg2381
DO - 10.1038/nrg2381
M3 - Review article
C2 - 18560438
AN - SCOPUS:45749158144
VL - 9
SP - 527
EP - 540
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
SN - 1471-0056
IS - 7
ER -