Psychiatric genetics: Progress amid controversy

Margit Burmeister, Melvin G. McInnis, Sebastian Zöllner

    Research output: Contribution to journalReview articlepeer-review

    364 Scopus citations


    Several psychiatric disorders - such as bipolar disorder, schizophrenia and autism - are highly heritable, yet identifying their genetic basis has been challenging, with most discoveries failing to be replicated. However, inroads have been made by the incorporation of intermediate traits (endophenotypes) and of environmental factors into genetic analyses, and through the identification of rare inherited variants and novel structural mutations. Current efforts aim to increase sample sizes by gathering larger samples for case-control studies or through meta-analyses of such studies. More attention on unique families, rare variants, and on incorporating environment and the emerging knowledge of biological function and pathways into genetic analysis is warranted.

    Original languageEnglish (US)
    Pages (from-to)527-540
    Number of pages14
    JournalNature Reviews Genetics
    Issue number7
    StatePublished - Jul 2008

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics
    • Genetics(clinical)


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