TY - JOUR
T1 - Psychiatric brain banking
T2 - Three perspectives on current trends and future directions
AU - Deep-Soboslay, Amy
AU - Benes, Francine M.
AU - Haroutunian, Vahram
AU - Ellis, Justin K.
AU - Kleinman, Joel E.
AU - Hyde, Thomas M.
N1 - Funding Information:
This research was supported in part by the Intramural Research Program of the National Institutes of Health , National Institute of Mental Health (AD-S, JKE, JEK, TMH); National Institutes of Health Grant R24 MH/NS 077550-06 ( R01 MH/NS 31862-28 ) (FMB); and National Institutes of Health Grants MH066392 , AG02219 , and AG05138 (VH).
Funding Information:
The National Institute of Mental Health Brain Tissue Collection, founded in 1977, currently maintains approximately 1026 brain tissue samples (acquired from 1992 to present; with previously acquired tissue depleted or discarded). The NIMH-BTC is funded by the National Institute of Mental Health Intramural Research Program and is maintained by the Section on Neuropathology in the Clinical Brain Disorders Branch. Cases are collected from the Offices of the Chief Medical Examiner of Northern Virginia and of the District of Columbia, and consent is obtained and audiotaped with the legal next of kin at the time of autopsy. Approximately 25% to 30% of contacted families consent to tissue donation, which results in an annual accrual rate of about 70 cases.
PY - 2011/1/15
Y1 - 2011/1/15
N2 - Postmortem human brain tissue is critical for advancing neurobiological studies of psychiatric illness, particularly for identifying brain-specific transcripts and isoforms. State-of-the-art methods and recommendations for maintaining psychiatric brain banks are discussed in three disparate collections, the National Institute of Mental Health Brain Tissue Collection, the Harvard Brain Tissue Resource Center, and the Mount Sinai School of Medicine Alzheimer's Disease and Schizophrenia Brain Bank. While the National Institute of Mental Health Brain Tissue Collection obtains donations from medical examiners and focuses on clinical diagnosis, toxicology, and building life span control cohorts, the Harvard Brain Tissue Resource Center is designed as a repository to collect large-volume, high-quality brain tissue from community-based donors across a nationwide network, placing emphasis on the accessibility of tissue and related data to research groups worldwide. The Mount Sinai School of Medicine Alzheimer's Disease and Schizophrenia Brain Bank has shown that prospective recruitment is a successful approach to tissue donation, placing particular emphasis on clinical diagnosis through antemortem contact with donors, as well as stereological tissue sampling methods for neuroanatomical studies and frozen tissue sampling approaches that enable multiple assessments (e.g., RNA, DNA, protein, enzyme activity, binding) of the same tissue block. Promising scientific approaches for elucidating the molecular and cellular pathways in brain that may contribute to schizophrenia are briefly discussed. Despite different perspectives from three established brain collections, there is consensus that varied networking strategies, rigorous tissue and clinical characterization, sample and data accessibility, and overall adaptability are integral to the success of psychiatric brain banking.
AB - Postmortem human brain tissue is critical for advancing neurobiological studies of psychiatric illness, particularly for identifying brain-specific transcripts and isoforms. State-of-the-art methods and recommendations for maintaining psychiatric brain banks are discussed in three disparate collections, the National Institute of Mental Health Brain Tissue Collection, the Harvard Brain Tissue Resource Center, and the Mount Sinai School of Medicine Alzheimer's Disease and Schizophrenia Brain Bank. While the National Institute of Mental Health Brain Tissue Collection obtains donations from medical examiners and focuses on clinical diagnosis, toxicology, and building life span control cohorts, the Harvard Brain Tissue Resource Center is designed as a repository to collect large-volume, high-quality brain tissue from community-based donors across a nationwide network, placing emphasis on the accessibility of tissue and related data to research groups worldwide. The Mount Sinai School of Medicine Alzheimer's Disease and Schizophrenia Brain Bank has shown that prospective recruitment is a successful approach to tissue donation, placing particular emphasis on clinical diagnosis through antemortem contact with donors, as well as stereological tissue sampling methods for neuroanatomical studies and frozen tissue sampling approaches that enable multiple assessments (e.g., RNA, DNA, protein, enzyme activity, binding) of the same tissue block. Promising scientific approaches for elucidating the molecular and cellular pathways in brain that may contribute to schizophrenia are briefly discussed. Despite different perspectives from three established brain collections, there is consensus that varied networking strategies, rigorous tissue and clinical characterization, sample and data accessibility, and overall adaptability are integral to the success of psychiatric brain banking.
KW - Brain banks
KW - brain collections
KW - postmortem human brain
KW - psychiatric
KW - psychosis
KW - schizophrenia
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U2 - 10.1016/j.biopsych.2010.05.025
DO - 10.1016/j.biopsych.2010.05.025
M3 - Review article
C2 - 20673875
AN - SCOPUS:78650487294
SN - 0006-3223
VL - 69
SP - 104
EP - 112
JO - Biological psychiatry
JF - Biological psychiatry
IS - 2
ER -