Pseudoxanthoma Elasticum and Mitral-Valve Prolapse

Reed E. Pyeritz, James L. Weiss, William A. Renie, Sturart L. Fine, Mark G. Lebwohl, Douglas Distefano, Philip G. Prioleau, Martin Uram, Lawrence A. Yannuzzi, Raul Fleischmajer

Research output: Contribution to journalLetterpeer-review

Abstract

To the Editor: Lebwohl and colleagues1 performed M-mode echocardiography on 14 patients affected by pseudoxanthoma elasticum and found mitral-valve prolapse in 11 (71 per cent) (July 22 issue). We are conducting a multidisciplinary assessment of pseudoxanthoma elasticum. Preliminary results (unpublished) of cardiologic examinations in 28 unrelated patients do not confirm this high prevalence of mitral-valve prolapse. None of the 17 women or 11 men (mean age, 43.3 years; range, 13 to 71 years) hada systolic click, and only one had an apical systolic murmur. M-mode echocardiograms in 16 patients showed mitral-valve prolapse in 1. Two-dimensional echocardiograms in 26 patients.

Original languageEnglish (US)
Pages (from-to)1451-1452
Number of pages2
JournalNew England Journal of Medicine
Volume307
Issue number23
DOIs
StatePublished - Dec 2 1982

ASJC Scopus subject areas

  • Medicine(all)

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