Pseudotumoral hemicerebellitis as a mimicker of Lhermitte-Duclos disease in children: does neuroimaging help to differentiate them?

Thangamadhan Bosemani, Maja Steinlin, Sandra P. Toelle, Jürgen Beck, Eugen Boltshauser, Thierry A.G.M. Huisman, Andrea Poretti

Research output: Contribution to journalArticle

Abstract

The clinical presentation and neuroimaging findings of children with pseudotumoral hemicerebellitis (PTHC) and Lhermitte-Duclos disease (LDD) may be very similar. The differentiation between these entities, however, is important because their management and prognosis are different. We report on three children with PTHC. For all three children, in the acute situation, the differentiation between PTHC and LDD was challenging. A review of the literature shows that a detailed evaluation of conventional and neuroimaging data may help to differentiate between these two entities. A striated folial pattern, brainstem involvement, and prominent veins surrounding the thickened cerebellar foliae on susceptibility weighted imaging favor LDD, while post-contrast enhancement and an increased choline peak on 1H-Magnetic resonance spectroscopy suggest PTHC.

Original languageEnglish (US)
Pages (from-to)865-871
Number of pages7
JournalChild's Nervous System
Volume32
Issue number5
DOIs
StatePublished - May 1 2016

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Keywords

  • Children
  • Imaging
  • Lhermitte-Duclos disease
  • Pseudotumoral hemicerebellitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Bosemani, T., Steinlin, M., Toelle, S. P., Beck, J., Boltshauser, E., Huisman, T. A. G. M., & Poretti, A. (2016). Pseudotumoral hemicerebellitis as a mimicker of Lhermitte-Duclos disease in children: does neuroimaging help to differentiate them? Child's Nervous System, 32(5), 865-871. https://doi.org/10.1007/s00381-015-2977-y