TY - JOUR
T1 - Pseudotumoral hemicerebellitis as a mimicker of Lhermitte-Duclos disease in children
T2 - does neuroimaging help to differentiate them?
AU - Bosemani, Thangamadhan
AU - Steinlin, Maja
AU - Toelle, Sandra P.
AU - Beck, Jürgen
AU - Boltshauser, Eugen
AU - Huisman, Thierry A.G.M.
AU - Poretti, Andrea
N1 - Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - The clinical presentation and neuroimaging findings of children with pseudotumoral hemicerebellitis (PTHC) and Lhermitte-Duclos disease (LDD) may be very similar. The differentiation between these entities, however, is important because their management and prognosis are different. We report on three children with PTHC. For all three children, in the acute situation, the differentiation between PTHC and LDD was challenging. A review of the literature shows that a detailed evaluation of conventional and neuroimaging data may help to differentiate between these two entities. A striated folial pattern, brainstem involvement, and prominent veins surrounding the thickened cerebellar foliae on susceptibility weighted imaging favor LDD, while post-contrast enhancement and an increased choline peak on 1H-Magnetic resonance spectroscopy suggest PTHC.
AB - The clinical presentation and neuroimaging findings of children with pseudotumoral hemicerebellitis (PTHC) and Lhermitte-Duclos disease (LDD) may be very similar. The differentiation between these entities, however, is important because their management and prognosis are different. We report on three children with PTHC. For all three children, in the acute situation, the differentiation between PTHC and LDD was challenging. A review of the literature shows that a detailed evaluation of conventional and neuroimaging data may help to differentiate between these two entities. A striated folial pattern, brainstem involvement, and prominent veins surrounding the thickened cerebellar foliae on susceptibility weighted imaging favor LDD, while post-contrast enhancement and an increased choline peak on 1H-Magnetic resonance spectroscopy suggest PTHC.
KW - Children
KW - Imaging
KW - Lhermitte-Duclos disease
KW - Pseudotumoral hemicerebellitis
UR - http://www.scopus.com/inward/record.url?scp=84949506018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949506018&partnerID=8YFLogxK
U2 - 10.1007/s00381-015-2977-y
DO - 10.1007/s00381-015-2977-y
M3 - Article
C2 - 26649682
AN - SCOPUS:84949506018
SN - 0256-7040
VL - 32
SP - 865
EP - 871
JO - Child's Nervous System
JF - Child's Nervous System
IS - 5
ER -