Pseudotumor Cerebri and Hypothyroidism

Oliver W. Press, Paul W. Ladenson

Research output: Contribution to journalArticlepeer-review

Abstract

A 38-year-old obese woman with concurrent hypothyroidism and pseudotumor cerebri was monitored with serial thyroid function tests and CSF pressure determinations during levothyroxine sodium replacement therapy. Following normalization of the patient's thyroid status, assessed by both clinical and chemical indexes (serum thyroxine level, 1.5 to 11.0 μg/dL; serum thyrotropin level, 128 to 1.5 μU/mL), intracranial hypertension persisted for more than four months. After weight loss, acetazolamide therapy, and intermittent CSF drainage failed to produce remission, glucocorticoid therapy was associated with prompt, sustained resolution of the pseudotumor cerebri. Contrary to previous reports, this patient's clinical course suggests that thyroid hormone deficiency and pseudotumor cerebri are not causally related.

Original languageEnglish (US)
Pages (from-to)167-168
Number of pages2
JournalArchives of internal medicine
Volume143
Issue number1
DOIs
StatePublished - Jan 1983
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine

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