Pseudophakic Candida parapsilosis endophthalmitis with a consecutive keratitis

S. Fekrat, J. A. Haller, W. R. Green, John D Gottsch

Research output: Contribution to journalArticle

Abstract

We describe a case of Candida parapsilosis endophthalmitis with a consecutive keratitis after phacoemulsification and posterior chamber intraocular lens implantation in an otherwise healthy eye. Despite aggressive medical and surgical management during a 2-year period, multiple episodes recurred, with the development of an intracapsular plaque and an infectious nidus on the corneal endothelium 6 months after the initial presentation. After subtotal removal of the culture-positive capsule, intravitreal and topical amphotericin B, and oral fluconazole, the inflammation improved. However, the corneal endothelial plaque persisted with recurrent inflammation 2 months later, prompting debridement of the culture-positive plaque and further removal of the culture-negative capsular remnants and lens implant. The infection was quiescent for the subsequent 12-month period until recurrent intraocular inflammation developed with enlargement of the endothelial plaque. Culture of this plaque was again positive for C. parapsilosis. After debridement and intra-ocular and topical amphotericin B, the eye has now been quiescent for 13 months. This case demonstrates the development of a secondary keratitis in an eye affected by pseudophakic C. parapsilosis endophthalmitis, with the posterior cornea serving as a sanctuary site for the fungus despite aggressive management leading to recurrent infection 1 year after the clinical disease appeared to be quiescent.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalCornea
Volume14
Issue number2
StatePublished - 1995

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Endophthalmitis
Keratitis
Candida
Amphotericin B
Debridement
Inflammation
Corneal Endothelium
Intraocular Lens Implantation
Phacoemulsification
Fluconazole
Infection
Cornea
Lenses
Capsules
Fungi

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Fekrat, S., Haller, J. A., Green, W. R., & Gottsch, J. D. (1995). Pseudophakic Candida parapsilosis endophthalmitis with a consecutive keratitis. Cornea, 14(2), 212-216.

Pseudophakic Candida parapsilosis endophthalmitis with a consecutive keratitis. / Fekrat, S.; Haller, J. A.; Green, W. R.; Gottsch, John D.

In: Cornea, Vol. 14, No. 2, 1995, p. 212-216.

Research output: Contribution to journalArticle

Fekrat, S, Haller, JA, Green, WR & Gottsch, JD 1995, 'Pseudophakic Candida parapsilosis endophthalmitis with a consecutive keratitis', Cornea, vol. 14, no. 2, pp. 212-216.
Fekrat, S. ; Haller, J. A. ; Green, W. R. ; Gottsch, John D. / Pseudophakic Candida parapsilosis endophthalmitis with a consecutive keratitis. In: Cornea. 1995 ; Vol. 14, No. 2. pp. 212-216.
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