Imaging description Small nodular hepatic early enhancing areas on multiphasic contrast-enhanced CT or MRI imaging can mimic malignant pathology. These early enhancing lesions are typically located in the periphery of the liver, measure only a few millimeters and are visible predominantly on the arterial phase of contrast imaging fading to isodensity/intensity on the delayed-phase imaging (Figures 74.1 and 74.2). Importantly, these lesions do not have a corresponding abnormality on the non-contrast T1-and T2-weighted MR imaging (Figure 74.3 and 74.4) and do not demonstrate restricted diffusion on diffusion-weighted imaging. Importance An arterioportal shunt occurs as result of a direct connection between the hepatic arterial and the portal venous systems and is an important cause of transient hepatic attenuation/intensity difference (THAD/THID). This tends to occur in the presence of diminished portal venous flow as in the case of cirrhosis or due to external factors such as trauma or percutaneous intervention. These pseudolesions have to be differentiated from malignant ones to avoid unwarranted anxiety in patients and to avoid invasive testing such as biopsy or even surgical resection. Typical clinical scenario These lesions may be a source of concern in patients with cirrhosis or a known malignancy with hypervascular metastasis such as renal cell carcinoma or neuroendocrine tumors. Due to their small size biopsy is usually not an option and these lesions tend to disappear or remain stable on the follow-up examinations (Figure 74.5). Differential diagnosis A small flash-filling hemangioma is typically very bright on T2-weighted MR imaging and typically retains contrast on the more delayed-phase imaging. Hepatocellular carcinoma and even metastatic disease from cancers like renal cell, melanoma or neuroendocrine tumors tend to washout on the venous and delayed-phase imaging and appear as lower density/intensity than the liver. The absence of washout on delayed imaging, peripheral location, small size, and absence of abnormality on T1-, T2-and diffusion-weighted imaging along with long-term stability are features of a benign process such as an arterioportal shunt.
|Original language||English (US)|
|Title of host publication||Pearls and Pitfalls in Cardiovascular Imaging|
|Subtitle of host publication||Pseudolesions, Artifacts and Other Difficult Diagnoses|
|Publisher||Cambridge University Press|
|Number of pages||3|
|State||Published - Jan 1 2015|
ASJC Scopus subject areas