Pseudo-isolated FSH deficiency caused by an inhibin B-secreting granulosa cell tumour: Case report

A. Krishnan, C. Murdock, J. Allard, M. Cisar, E. Reid, L. Nieman, J. Segars

Research output: Contribution to journalArticlepeer-review

Abstract

Isolated FSH deficiency due to a mutation in the FSHβ subunit is characterized by an extremely low serum FSH concentration. We report a patient who presented with an FSH of 0.8 mIU/ml and infertility associated with anovulation. Endocrinological assessment and immunohistochemistry revealed that a granulosa cell tumour was secreting inhibin B and suppressing FSH; however, LH and estradiol were within their normal ranges. Upon removal of the tumour, inhibin B decreased and FSH levels rose to normal values. The patient subsequently conceived and delivered successfully. Based on this case and on those previously described in the literature, we suggest that inhibin B levels should be evaluated in anovulatory patients having a clinical presentation consistent with functional hypothalamic amenorrhoea and very low to normal values of FSH.

Original languageEnglish (US)
Pages (from-to)502-505
Number of pages4
JournalHuman Reproduction
Volume18
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Keywords

  • FSH deficiency
  • Granulosa cell tumour
  • Hypothalamic amenorrhoea
  • Infertility
  • Inhibin B

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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