Pseudo-isolated FSH deficiency caused by an inhibin B-secreting granulosa cell tumour: Case report

A. Krishnan; C. Murdock; J. Allard; M. Cisar; E. Reid; L. Nieman; J. Segars

doi:10.1093/humrep/deg124

Pseudo-isolated FSH deficiency caused by an inhibin B-secreting granulosa cell tumour: Case report

A. Krishnan, C. Murdock, J. Allard, M. Cisar, E. Reid, L. Nieman, J. Segars

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Isolated FSH deficiency due to a mutation in the FSHβ subunit is characterized by an extremely low serum FSH concentration. We report a patient who presented with an FSH of 0.8 mIU/ml and infertility associated with anovulation. Endocrinological assessment and immunohistochemistry revealed that a granulosa cell tumour was secreting inhibin B and suppressing FSH; however, LH and estradiol were within their normal ranges. Upon removal of the tumour, inhibin B decreased and FSH levels rose to normal values. The patient subsequently conceived and delivered successfully. Based on this case and on those previously described in the literature, we suggest that inhibin B levels should be evaluated in anovulatory patients having a clinical presentation consistent with functional hypothalamic amenorrhoea and very low to normal values of FSH.

Original language	English (US)
Pages (from-to)	502-505
Number of pages	4
Journal	Human Reproduction
Volume	18
Issue number	3
DOIs	https://doi.org/10.1093/humrep/deg124
State	Published - Mar 1 2003
Externally published	Yes

Keywords

FSH deficiency
Granulosa cell tumour
Hypothalamic amenorrhoea
Infertility
Inhibin B

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1093/humrep/deg124

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abstract = "Isolated FSH deficiency due to a mutation in the FSHβ subunit is characterized by an extremely low serum FSH concentration. We report a patient who presented with an FSH of 0.8 mIU/ml and infertility associated with anovulation. Endocrinological assessment and immunohistochemistry revealed that a granulosa cell tumour was secreting inhibin B and suppressing FSH; however, LH and estradiol were within their normal ranges. Upon removal of the tumour, inhibin B decreased and FSH levels rose to normal values. The patient subsequently conceived and delivered successfully. Based on this case and on those previously described in the literature, we suggest that inhibin B levels should be evaluated in anovulatory patients having a clinical presentation consistent with functional hypothalamic amenorrhoea and very low to normal values of FSH.",

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AU - Allard, J.

AU - Cisar, M.

AU - Reid, E.

AU - Nieman, L.

AU - Segars, J.

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N2 - Isolated FSH deficiency due to a mutation in the FSHβ subunit is characterized by an extremely low serum FSH concentration. We report a patient who presented with an FSH of 0.8 mIU/ml and infertility associated with anovulation. Endocrinological assessment and immunohistochemistry revealed that a granulosa cell tumour was secreting inhibin B and suppressing FSH; however, LH and estradiol were within their normal ranges. Upon removal of the tumour, inhibin B decreased and FSH levels rose to normal values. The patient subsequently conceived and delivered successfully. Based on this case and on those previously described in the literature, we suggest that inhibin B levels should be evaluated in anovulatory patients having a clinical presentation consistent with functional hypothalamic amenorrhoea and very low to normal values of FSH.

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Pseudo-isolated FSH deficiency caused by an inhibin B-secreting granulosa cell tumour: Case report

Abstract

Keywords

ASJC Scopus subject areas

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