PSA Doubling Time Versus PSA Velocity to Predict High-Risk Prostate Cancer: Data from the Baltimore Longitudinal Study of Aging

Stacy Loeb, Anna Kettermann, Luigi Ferrucci, Patricia Landis, E. Jeffrey Metter, H Ballentine Carter

Research output: Contribution to journalArticle

Abstract

Background: Our group has previously shown that prostate-specific antigen (PSA) velocity (PSAV) is associated with the presence of life-threatening prostate cancer. Less is known about the relative utility of pretreatment PSA doubling time (PSA DT) to predict tumor aggressiveness. Objective: To compare the utility of PSAV and PSA DT for the prediction of life-threatening prostate cancer. Design, setting, and participants: From the Baltimore Longitudinal Study of Aging, we identified 681 men with serial PSA measurements. Measurements: Receiver operating characteristic analysis was used to evaluate the relationship between PSAV, PSA DT, and the presence of high-risk disease. Results and limitations: Within the period of 5 yr prior to diagnosis, PSAV was significantly higher among men with high-risk or fatal prostate cancer than men without it. By contrast, PSA DT was not significantly associated with high-risk or fatal disease. On multivariate analysis, including age, date of diagnosis, and PSA, the addition of PSAV significantly improved the concordance index from 0.85 to 0.88 (p <0.001), whereas PSA DT did not. Conclusions: These data suggest that PSAV is more useful than PSA DT in the pretreatment setting to help identify those men with life-threatening disease.

Original languageEnglish (US)
Pages (from-to)1073-1080
Number of pages8
JournalEuropean Urology
Volume54
Issue number5
DOIs
StatePublished - Nov 2008

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Baltimore
Prostate-Specific Antigen
Longitudinal Studies
Prostatic Neoplasms
ROC Curve
Multivariate Analysis

Keywords

  • Prognosis
  • Prostate cancer
  • PSA doubling time
  • PSA kinetics
  • PSA velocity

ASJC Scopus subject areas

  • Urology

Cite this

PSA Doubling Time Versus PSA Velocity to Predict High-Risk Prostate Cancer : Data from the Baltimore Longitudinal Study of Aging. / Loeb, Stacy; Kettermann, Anna; Ferrucci, Luigi; Landis, Patricia; Metter, E. Jeffrey; Carter, H Ballentine.

In: European Urology, Vol. 54, No. 5, 11.2008, p. 1073-1080.

Research output: Contribution to journalArticle

Loeb, Stacy ; Kettermann, Anna ; Ferrucci, Luigi ; Landis, Patricia ; Metter, E. Jeffrey ; Carter, H Ballentine. / PSA Doubling Time Versus PSA Velocity to Predict High-Risk Prostate Cancer : Data from the Baltimore Longitudinal Study of Aging. In: European Urology. 2008 ; Vol. 54, No. 5. pp. 1073-1080.
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