Prurigo nodularis: Epidemiology and clinical features

Amy H. Huang, Kyle A. Williams, Shawn G. Kwatra

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intensely pruritic, hyperkeratotic nodules that favor the extensor surfaces of the extremities and the trunk. In addition to its significant impact on quality of life, many patients with PN are recalcitrant to therapy because there are currently no therapies approved by the US Food and Drug Administration. In the first article of this 2-part continuing medical education series, we describe the broader epidemiology, patient demographics, physical examination findings, and symptoms to aid in the timely recognition and diagnosis of PN. Furthermore, we quantify the burden of comorbidities in PN by discussing the broad spectrum of systemic diseases and mental health conditions that have been associated with this condition. The second article of this 2-part series focuses on the pathogenesis of PN and provides detailed algorithms for comprehensive work-up and management.

Original languageEnglish (US)
Pages (from-to)1559-1565
Number of pages7
JournalJournal of the American Academy of Dermatology
Issue number6
StatePublished - Dec 2020


  • clinical features
  • comorbidities
  • epidemiology
  • itch
  • physical examination
  • prurigo nodularis
  • pruritus
  • symptoms

ASJC Scopus subject areas

  • Dermatology


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