Provider roles in the recruitment of underrepresented populations to cancer clinical trials

Mollie W. Howerton, M Christopher Gibbons, Charles R. Baffi, Tiffany L. Gary, Gabriel Y. Lai, Shari Bolen, Jon Tilburt, Teerath Peter Tanpitukpongse, Renee Wilson, Neil R. Powe, Eric B Bass, Jean G. Ford

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Providers play a vital role in the successful recruitment of underrepresented patients to cancer clinical trials because they often introduce the opportunity of clinical trials. The purpose of the current systematic review was to describe provider-related factors influencing recruitment of underrepresented populations to cancer clinical trials. METHODS. To find original studies on the recruitment of underrepresented populations to cancer clinical trials, electronic databases from January 1966 to December 2005 were searched; hand-searched titles in 34 journals from January 2003 to January 2006; and reference lists were examined of eligible articles. Title and abstract reviews were conducted to identify relevant studies. Potential articles were then abstracted using a structured instrument and a serial review process by 2 investigators. RESULTS. Eighteen studies were eligible for review: 13 targeted healthcare providers, 3 targeted patients/participants, and 2 targeted both providers and patients. The study designs included randomized controlled trial, concurrent controlled trial, case-control, descriptive, and qualitative. A lack of available protocols and/or a lack of provider awareness about clinical trials prevented providers from discussing the opportunity of clinical trials in 2 studies. In 14 studies, patient accrual was affected by provider attitudinal barriers relating to patient adherence to the study protocol, patient mistrust of research, patient costs, data collection costs, and/or patient eligibility. Providers' communication methods were barriers in 5 studies and promoters in 1 study. CONCLUSIONS. A heterogeneous body of evidence suggests that several provider-related factors influence recruitment of underrepresented groups to clinical trials. Future recruitment efforts should address these factors.

Original languageEnglish (US)
Pages (from-to)465-476
Number of pages12
JournalCancer
Volume109
Issue number3
DOIs
StatePublished - Feb 1 2007

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Clinical Trials
Population
Neoplasms
Costs and Cost Analysis
Patient Compliance
Health Personnel
Patient Selection
Randomized Controlled Trials
Communication
Research Personnel
Databases
Research

Keywords

  • Accrual
  • Cancer
  • Clinical trials
  • Minorities
  • Providers
  • Recruitment
  • Systematic review
  • Underrepresented populations
  • Underserved

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Howerton, M. W., Gibbons, M. C., Baffi, C. R., Gary, T. L., Lai, G. Y., Bolen, S., ... Ford, J. G. (2007). Provider roles in the recruitment of underrepresented populations to cancer clinical trials. Cancer, 109(3), 465-476. https://doi.org/10.1002/cncr.22436

Provider roles in the recruitment of underrepresented populations to cancer clinical trials. / Howerton, Mollie W.; Gibbons, M Christopher; Baffi, Charles R.; Gary, Tiffany L.; Lai, Gabriel Y.; Bolen, Shari; Tilburt, Jon; Tanpitukpongse, Teerath Peter; Wilson, Renee; Powe, Neil R.; Bass, Eric B; Ford, Jean G.

In: Cancer, Vol. 109, No. 3, 01.02.2007, p. 465-476.

Research output: Contribution to journalArticle

Howerton, MW, Gibbons, MC, Baffi, CR, Gary, TL, Lai, GY, Bolen, S, Tilburt, J, Tanpitukpongse, TP, Wilson, R, Powe, NR, Bass, EB & Ford, JG 2007, 'Provider roles in the recruitment of underrepresented populations to cancer clinical trials', Cancer, vol. 109, no. 3, pp. 465-476. https://doi.org/10.1002/cncr.22436
Howerton MW, Gibbons MC, Baffi CR, Gary TL, Lai GY, Bolen S et al. Provider roles in the recruitment of underrepresented populations to cancer clinical trials. Cancer. 2007 Feb 1;109(3):465-476. https://doi.org/10.1002/cncr.22436
Howerton, Mollie W. ; Gibbons, M Christopher ; Baffi, Charles R. ; Gary, Tiffany L. ; Lai, Gabriel Y. ; Bolen, Shari ; Tilburt, Jon ; Tanpitukpongse, Teerath Peter ; Wilson, Renee ; Powe, Neil R. ; Bass, Eric B ; Ford, Jean G. / Provider roles in the recruitment of underrepresented populations to cancer clinical trials. In: Cancer. 2007 ; Vol. 109, No. 3. pp. 465-476.
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abstract = "BACKGROUND. Providers play a vital role in the successful recruitment of underrepresented patients to cancer clinical trials because they often introduce the opportunity of clinical trials. The purpose of the current systematic review was to describe provider-related factors influencing recruitment of underrepresented populations to cancer clinical trials. METHODS. To find original studies on the recruitment of underrepresented populations to cancer clinical trials, electronic databases from January 1966 to December 2005 were searched; hand-searched titles in 34 journals from January 2003 to January 2006; and reference lists were examined of eligible articles. Title and abstract reviews were conducted to identify relevant studies. Potential articles were then abstracted using a structured instrument and a serial review process by 2 investigators. RESULTS. Eighteen studies were eligible for review: 13 targeted healthcare providers, 3 targeted patients/participants, and 2 targeted both providers and patients. The study designs included randomized controlled trial, concurrent controlled trial, case-control, descriptive, and qualitative. A lack of available protocols and/or a lack of provider awareness about clinical trials prevented providers from discussing the opportunity of clinical trials in 2 studies. In 14 studies, patient accrual was affected by provider attitudinal barriers relating to patient adherence to the study protocol, patient mistrust of research, patient costs, data collection costs, and/or patient eligibility. Providers' communication methods were barriers in 5 studies and promoters in 1 study. CONCLUSIONS. A heterogeneous body of evidence suggests that several provider-related factors influence recruitment of underrepresented groups to clinical trials. Future recruitment efforts should address these factors.",
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