Proton overhauser enhancements in human cardiac phosphorus NMR spectroscopy at 1.5 T

Paul A Bottomley, C. J. Hardy

Research output: Contribution to journalArticle

Abstract

Narrowband irradiation of water protons with a surface coil yields significant nuclear Overhauser enhancement (nOe) of phosphocreatine (PCr) and some adenosine triphosphate (ATP) moieties in localized and unlocalized phosphorus (31P) NMR spectra from chest and heart muscle. In seven normal subjects at 1.5 T the nOe values were 0.6 ± 0.3, 0.6 ± 0.3, 0 ± 0.3, and 0.3 ± 0.2 for myocardial PCr, γ-ATP, α-ATP, and β-ATP, respectively, not significantly different from those in chest muscle. Distortion of the measured PCr/ATP ratios due to differences in the nOe may require accurate correction to realize the full benefit of the effect in studies involving quantitative intergroup comparisons.

Original languageEnglish (US)
Pages (from-to)384-390
Number of pages7
JournalMagnetic Resonance in Medicine
Volume24
Issue number2
StatePublished - 1992
Externally publishedYes

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Phosphorus
Protons
Magnetic Resonance Spectroscopy
Adenosine Triphosphate
Phosphocreatine
Thorax
Myocardium
Muscles
Water

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Proton overhauser enhancements in human cardiac phosphorus NMR spectroscopy at 1.5 T. / Bottomley, Paul A; Hardy, C. J.

In: Magnetic Resonance in Medicine, Vol. 24, No. 2, 1992, p. 384-390.

Research output: Contribution to journalArticle

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