Proton NMR spectroscopy of Canavan's disease

P. B. Barker, R. N. Bryan, A. J. Kumar, S. Naidu

Research output: Contribution to journalArticle

Abstract

Proton Nuclear Magnetic Resonance (NMR) spectroscopy was used to quantitatively determine cerebral N-Acetyl Aspartate (NAA) concentrations in four patients with Canavan's disease and in four age-matched control subjects. Macroscopic NAA concentrations (μmol/ gm wet weight) were not found to be significantly different from controls. Reduced levels of choline and creatine were observed in all patients, and increased levels of lactate and inositol in the eldest three patients.

Original languageEnglish (US)
Pages (from-to)263-267
Number of pages5
JournalNeuropediatrics
Volume23
Issue number5
DOIs
StatePublished - Jan 1 1992

Keywords

  • Canavan's disease
  • N-acetyl-aspartate
  • NMR spectroscopy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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