Abstract
We have noninvasively detected the proton signal of an antineoplastic agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel‐MQC). Without isotopic labeling or chemical modification, the Sel‐MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
Original language | English (US) |
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Pages (from-to) | 414-416 |
Number of pages | 3 |
Journal | Magnetic resonance in medicine |
Volume | 33 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1995 |
Keywords
- drug detection
- in vivo H NMR
- tumors
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging