Proton NMR Observation of the Antineoplastic Agent Iproplatin In Vivo by Selective Multiple Quantum Coherence Transfer (Sel‐MQC)

Qiuhong He, Zaver M. Bhujwalla, Ross J. Maxwell, John R. Griffiths, Jerry D. Glickson

Research output: Contribution to journalArticle

Abstract

We have noninvasively detected the proton signal of an antineoplastic agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel‐MQC). Without isotopic labeling or chemical modification, the Sel‐MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.

Original languageEnglish (US)
Pages (from-to)414-416
Number of pages3
JournalMagnetic resonance in medicine
Volume33
Issue number3
DOIs
StatePublished - Mar 1995

Keywords

  • drug detection
  • in vivo H NMR
  • tumors

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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