Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions

Ty K. Subhawong; Xin Wang; Daniel J. Durand; Michael A. Jacobs; John A. Carrino; Antonio J. Machado; Laura M. Fayad

doi:10.2214/AJR.11.6505

Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions

Ty K. Subhawong, Xin Wang, Daniel J. Durand, Michael A. Jacobs, John A. Carrino, Antonio J. Machado, Laura M. Fayad

School of Medicine

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

OBJECTIVE. The purposes of this review are to describe the principles and method of MR spectroscopy, summarize current published data on musculoskeletal lesions, and report additional cases that have been analyzed with recently developed quantitative methods. CONCLUSION. Proton MR spectroscopy can be used to identify key tissue metabolites and may serve as a useful adjunct to radiographic evaluation of musculoskeletal lesions. A pooled analysis of 122 musculoskeletal tumors revealed that a discrete choline peak has a sensitivity of 88% and specificity of 68% in the detection of malignancy. Modest improvements in diagnostic accuracy in 22 of 122 cases when absolute choline quantification was used encourage the pursuit of development of choline quantification methods.

Original language	English (US)
Pages (from-to)	162-172
Number of pages	11
Journal	American Journal of Roentgenology
Volume	198
Issue number	1
DOIs	https://doi.org/10.2214/AJR.11.6505
State	Published - Jan 2012

Keywords

Choline
MR spectroscopy
MRI
Musculoskeletal
Tumor

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.2214/AJR.11.6505

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title = "Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions",

abstract = "OBJECTIVE. The purposes of this review are to describe the principles and method of MR spectroscopy, summarize current published data on musculoskeletal lesions, and report additional cases that have been analyzed with recently developed quantitative methods. CONCLUSION. Proton MR spectroscopy can be used to identify key tissue metabolites and may serve as a useful adjunct to radiographic evaluation of musculoskeletal lesions. A pooled analysis of 122 musculoskeletal tumors revealed that a discrete choline peak has a sensitivity of 88% and specificity of 68% in the detection of malignancy. Modest improvements in diagnostic accuracy in 22 of 122 cases when absolute choline quantification was used encourage the pursuit of development of choline quantification methods.",

keywords = "Choline, MR spectroscopy, MRI, Musculoskeletal, Tumor",

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T1 - Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions

AU - Subhawong, Ty K.

AU - Wang, Xin

AU - Durand, Daniel J.

AU - Jacobs, Michael A.

AU - Carrino, John A.

AU - Machado, Antonio J.

AU - Fayad, Laura M.

PY - 2012/1

Y1 - 2012/1

N2 - OBJECTIVE. The purposes of this review are to describe the principles and method of MR spectroscopy, summarize current published data on musculoskeletal lesions, and report additional cases that have been analyzed with recently developed quantitative methods. CONCLUSION. Proton MR spectroscopy can be used to identify key tissue metabolites and may serve as a useful adjunct to radiographic evaluation of musculoskeletal lesions. A pooled analysis of 122 musculoskeletal tumors revealed that a discrete choline peak has a sensitivity of 88% and specificity of 68% in the detection of malignancy. Modest improvements in diagnostic accuracy in 22 of 122 cases when absolute choline quantification was used encourage the pursuit of development of choline quantification methods.

AB - OBJECTIVE. The purposes of this review are to describe the principles and method of MR spectroscopy, summarize current published data on musculoskeletal lesions, and report additional cases that have been analyzed with recently developed quantitative methods. CONCLUSION. Proton MR spectroscopy can be used to identify key tissue metabolites and may serve as a useful adjunct to radiographic evaluation of musculoskeletal lesions. A pooled analysis of 122 musculoskeletal tumors revealed that a discrete choline peak has a sensitivity of 88% and specificity of 68% in the detection of malignancy. Modest improvements in diagnostic accuracy in 22 of 122 cases when absolute choline quantification was used encourage the pursuit of development of choline quantification methods.

KW - Choline

KW - MR spectroscopy

KW - MRI

KW - Musculoskeletal

KW - Tumor

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Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions

Abstract

Keywords

ASJC Scopus subject areas

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