Proton MR spectroscopic imaging without water suppression

J. W.C. Van der Veen, D. R. Weinberger, G. Tedeschi, J. A. Frank, J. F. Duyn

Research output: Contribution to journalArticlepeer-review


To improve reproducibility in proton magnetic resonance (MR) spectroscopic imaging in human brain, simultaneous acquisition of the internal water reference and metabolite signals was evaluated. Measurements in healthy volunteers showed that the increase in dynamic range from signal oversampling was sufficient to avoid digitization errors. In addition, use of singular value decomposition techniques and finite impulse response filters proved effective in separating water and metabolite signals and providing estimates of the metabolite concentrations.

Original languageEnglish (US)
Pages (from-to)296-300
Number of pages5
Issue number1
StatePublished - 2000
Externally publishedYes


  • Brain, metabolism Brain, MR
  • Magnetic resonance (MR)
  • Magnetic resonance (MR) physics
  • Magnetic resonance (MR), pulse
  • Reconstruction algorithms
  • Sequences
  • Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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