Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia: In vivo-in vitro (ex vivo) correlation

Thierry A G M Huisman, T. Thiel, B. Steinmann, G. Zeilinger, E. Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.

Original languageEnglish (US)
Pages (from-to)858-861
Number of pages4
JournalEuropean Radiology
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2002
Externally publishedYes

Keywords

  • Brain
  • MR spectroscopy
  • Neonate
  • Non-ketotic hyperglycinemia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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