Abstract
Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 858-861 |
| Number of pages | 4 |
| Journal | European Radiology |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2002 |
| Externally published | Yes |
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Keywords
- Brain
- MR spectroscopy
- Neonate
- Non-ketotic hyperglycinemia
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia : In vivo-in vitro (ex vivo) correlation. / Huisman, Thierry A G M; Thiel, T.; Steinmann, B.; Zeilinger, G.; Martin, E.
In: European Radiology, Vol. 12, No. 4, 01.04.2002, p. 858-861.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia
T2 - In vivo-in vitro (ex vivo) correlation
AU - Huisman, Thierry A G M
AU - Thiel, T.
AU - Steinmann, B.
AU - Zeilinger, G.
AU - Martin, E.
PY - 2002/4/1
Y1 - 2002/4/1
N2 - Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.
AB - Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.
KW - Brain
KW - MR spectroscopy
KW - Neonate
KW - Non-ketotic hyperglycinemia
UR - http://www.scopus.com/inward/record.url?scp=0036549393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036549393&partnerID=8YFLogxK
U2 - 10.1007/s003300101073
DO - 10.1007/s003300101073
M3 - Article
C2 - 11960238
AN - SCOPUS:0036549393
VL - 12
SP - 858
EP - 861
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 4
ER -