Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia: In vivo-in vitro (ex vivo) correlation

Thierry A G M Huisman; T. Thiel; B. Steinmann; G. Zeilinger; E. Martin

doi:10.1007/s003300101073

Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia: In vivo-in vitro (ex vivo) correlation

Thierry A G M Huisman, T. Thiel, B. Steinmann, G. Zeilinger, E. Martin

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (¹H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, ¹H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.

Original language	English (US)
Pages (from-to)	858-861
Number of pages	4
Journal	European Radiology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1007/s003300101073
State	Published - Apr 1 2002
Externally published	Yes

Keywords

Brain
MR spectroscopy
Neonate
Non-ketotic hyperglycinemia

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

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10.1007/s003300101073

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abstract = "Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.",

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AU - Steinmann, B.

AU - Zeilinger, G.

AU - Martin, E.

PY - 2002/4/1

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N2 - Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.

AB - Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.

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KW - MR spectroscopy

KW - Neonate

KW - Non-ketotic hyperglycinemia

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Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia: In vivo-in vitro (ex vivo) correlation

Abstract

Keywords

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