Abstract
Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.
Original language | English (US) |
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Pages (from-to) | 858-861 |
Number of pages | 4 |
Journal | European Radiology |
Volume | 12 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2002 |
Externally published | Yes |
Keywords
- Brain
- MR spectroscopy
- Neonate
- Non-ketotic hyperglycinemia
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology