Proton magnetic resonance spectroscopy of choroid plexus tumors in children

Alena Horská, Aziz M. Uluǧ, Elias R. Melhem, Christopher G. Filippi, Peter C. Burger, Mark A. Edgar, Mark M. Souweidane, Benjamin S. Carson, Peter B. Barker

Research output: Contribution to journalArticlepeer-review

Abstract

A variety of lesions may present as intraventricular masses in children. We report quantitative proton magnetic resonance spectroscopy (MRS) of two intraventricular tumors of the choroid plexus: choroid plexus carcinoma (CPC) and choroid plexus papilloma (CPP). Both lesions were characterized by high levels of choline-containing compounds and a complete absence of creatine and the neuronal/axonal marker N-acetyl aspartate. The CPC showed higher levels of choline compared to the CPP, and it also had elevated lactate. These preliminary results, if confirmed in a larger cohort of patients, indicate that proton MRS may have a role in the presurgical diagnosis of choroid plexus tumors in children, which may also have important implications for therapy and prognosis.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume14
Issue number1
DOIs
StatePublished - Jul 10 2001

Keywords

  • Brain tumors
  • Carcinoma
  • Choroid plexus
  • H MR spectroscopy
  • Papilloma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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