Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: A pilot investigation comparing treatment responders and non-responders

Mona Mohamed, Mari A. Smith, Michael W. Schlund, Gerald Nestadt, Peter B Barker, Rudolf Hoehn-Saric

Research output: Contribution to journalArticle

Abstract

Proton magnetic resonance spectroscopic imaging was performed to compare brain metabolism in patients with obsessive-compulsive OCD. Evaluation was done on responders and non-responders to pharmacotherapy and on healthy controls. The results showed significantly lower NAA/Cr ratios in the right basal ganglia in non-responders than in responders or in controls and higher Cho/Cr ratios in the right thalamus in non-responders than responders. Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume156
Issue number2
DOIs
StatePublished - Nov 15 2007

Fingerprint

Obsessive-Compulsive Disorder
Basal Ganglia
Thalamus
Serotonin Uptake Inhibitors
Protons
Magnetic Resonance Imaging
Drug Therapy
Brain
Therapeutics
Proton Magnetic Resonance Spectroscopy

Keywords

  • brain metabolism
  • OCD
  • SSRI
  • treatment non-responders
  • treatment responders

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

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