Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma

Bayram Cirak, Alena Horská, Peter B. Barker, Peter C. Burger, Benjamin S. Carson, Anthony M. Avellino

Research output: Contribution to journalArticlepeer-review

Abstract

Objects: A pilomyxoid astrocytoma (PmA) is considered to be either a more aggressive variant of a pediatric pilocytic astrocytoma (PA) or a tumor of a separate entity. Methods: We present two cases of pediatric optic-chiasmatic PmA. Proton magnetic resonance spectroscopic imaging (MRSI) of the PmA revealed decreased concentrations of total choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA). In contrast, proton MR spectra of PAs showed elevated Cho and decreased Cr and NAA signals. Conclusion: Low metabolite concentrations in PmAs detected by MRSI may therefore help to distinguish PmAs from PAs preoperatively.

Original languageEnglish (US)
Pages (from-to)404-409
Number of pages6
JournalChild's Nervous System
Volume21
Issue number5
DOIs
StatePublished - May 1 2005

Keywords

  • Pediatric brain tumor
  • Pilocytic astrocytoma
  • Pilomyxoid astrocytoma
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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