Proton imaging and phosphorus spectroscopy in a malignant glioma

R. A. Zimmerman, P. A. Bottomley, W. A. Edelstein, H. R. Hart, R. W. Redington, L. T. Bilaniuk, R. I. Grossman, H. I. Goldberg, L. Bruno, H. Kressel

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Since 1980 several papers have detailed the value of 1H magnetic resonance imaging (MRI) of the central nervous system as being clinically useful. Recently, Cady et al. used 31P MRI to study the cerebral metabolism of newborn infants suffering birth asphyxia, meningitis, congenital abnormalities, and cerebral edema. Bottomley et al. described the first in vivo 31P spectra and high-field 1H MR images in a normal adult volunteer. We now report both 1H MR images and 3P MR chemical-shift spectroscopic studies in a patient with a malignant glioma of the left temporal parietal lobe undergoing radiation and chemotherapy. The ability to perform both 1H imaging and in vivo phosphorus spectroscopy with the same instrument with only a 5-10 min changeover delay opens a new avenue in the investigation of neurologic diseases.

Original languageEnglish (US)
Pages (from-to)109-110
Number of pages2
JournalAmerican Journal of Neuroradiology
Issue number1
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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